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Subject collection: Tools and Resources for Mouse Studies

  • SPECIAL ARTICLE
    Predicting human disease mutations and identifying drug targets from mouse gene knockout phenotyping campaigns
    Robert Brommage, David R. Powell, Peter Vogel
    Disease Models & Mechanisms 2019 12: dmm038224 doi: 10.1242/dmm.038224 Published 7 May 2019

    Summary: Large-scale, focused phenotyping campaigns provide data for thousands of mutant mouse genes, yielding key information for understanding rare human diseases and for developing novel drug therapies.

  • AT A GLANCE
    Generating mouse models for biomedical research: technological advances
    Channabasavaiah B. Gurumurthy, Kevin C. Kent Lloyd
    Disease Models & Mechanisms 2019 12: dmm029462 doi: 10.1242/dmm.029462 Published 8 January 2019

    Summary: Newer molecular technologies to precisely and efficiently manipulate the mammalian genome are enabling the production of more scientifically valuable animal models.

  • RESEARCH ARTICLE
    Pathogenic and non-pathogenic Escherichia coli colonization and host inflammatory response in a defined microbiota mouse model
    Zachary R. Stromberg, Angelica Van Goor, Graham A. J. Redweik, Meghan J. Wymore Brand, Michael J. Wannemuehler, Melha Mellata
    Disease Models & Mechanisms 2018 11: dmm035063 doi: 10.1242/dmm.035063 Published 16 November 2018

    Summary: Mice harboring a defined microbiota of the altered Schaedler flora were identified as a reliable tool to assess prolonged Escherichia coli intestinal colonization and activation of the host inflammatory response.

  • SPECIAL ARTICLE
    Living inside the box: environmental effects on mouse models of human disease
    John P. Sundberg, Paul N. Schofield
    Disease Models & Mechanisms 2018 11: dmm035360 doi: 10.1242/dmm.035360 Published 1 October 2018

    Summary: The utility of mice as models of human disease is often questioned because they live in a controlled laboratory environment, unlike humans. The authors compare the environments of humans and mice, and find parallels, suggesting that they are not so different. Understanding how mouse and human environments affect phenotypes is critical for the development of models of human disease.

  • RESOURCE ARTICLE
    Growth of human breast cancers in Peromyscus
    Vimala Kaza, Elena Farmaki, Amanda Havighorst, Janet Crossland, Ioulia Chatzistamou, Hippokratis Kiaris
    Disease Models & Mechanisms 2018 11: dmm031302 doi: 10.1242/dmm.031302 Published 17 January 2018

    Summary: Outbred stocks of Peromyscus californicus (California mice), upon pharmacological immunosuppression, provide an alternative to conventional inbred mice models, and can support the growth of hormone-insensitive and hormone-sensitive human breast cancers.

  • RESOURCE ARTICLE
    Generation of a multipurpose Prdm16 mouse allele by targeted gene trapping
    Alexander Strassman, Frank Schnütgen, Qi Dai, Jennifer C. Jones, Angela C. Gomez, Lenore Pitstick, Nathan E. Holton, Russell Moskal, Erin R. Leslie, Harald von Melchner, David R. Beier, Bryan C. Bjork
    Disease Models & Mechanisms 2017 10: 909-922; doi: 10.1242/dmm.029561

    Summary: Described is the first targeting of an invertible gene trap to generate a conditional Prdm16 mouse allele and its use to assess phenotypic consequences of Prdm16 loss during craniofacial and brain development.

  • SPECIAL ARTICLE
    Show and tell: disclosure and data sharing in experimental pathology
    Paul N. Schofield, Jerrold M. Ward, John P. Sundberg
    Disease Models & Mechanisms 2016 9: 601-605; doi: 10.1242/dmm.026054

    Summary: Reproducibility of findings in experiments using model organisms has recently become a source of concern, particularly for translational science. We discuss factors affecting the interpretation and reliability of experimental pathology findings in the mouse, and how disclosure and transparent reporting are crucial for replicability.

  • EDITORIAL
    Using the mouse to model human disease: increasing validity and reproducibility
    Monica J. Justice, Paraminder Dhillon
    Disease Models & Mechanisms 2016 9: 101-103; doi: 10.1242/dmm.024547

    Summary: Raising standards for carrying out and reporting mouse model studies will improve reproducibility and relevance to human disease research.

  • RESOURCE ARTICLE
    Generation of brain tumours in mice by Cre-mediated recombination of neural progenitors in situ with the tamoxifen metabolite endoxifen
    Anna Benedykcinska, Andreia Ferreira, Joanne Lau, Jessica Broni, Angela Richard-Loendt, Nico V. Henriquez, Sebastian Brandner
    Disease Models & Mechanisms 2016 9: 211-220; doi: 10.1242/dmm.022715

    Summary: An active tamoxifen derivative can be used for the in vivo induction of recombination in situ in mice by CreERT2. We show how this method can be used to generate brain tumours through recombination of tumour suppressor genes in the subventricular zone.

  • RESOURCE ARTICLE
    CLARITY and PACT-based imaging of adult zebrafish and mouse for whole-animal analysis of infections
    Mark R. Cronan, Allison F. Rosenberg, Stefan H. Oehlers, Joseph W. Saelens, Dana M. Sisk, Kristen L. Jurcic Smith, Sunhee Lee, David M. Tobin
    Disease Models & Mechanisms 2015 8: 1643-1650; doi: 10.1242/dmm.021394

    Summary: The authors apply the CLARITY and PACT techniques to image infectious structures located deep within whole adult zebrafish and mouse organs, enabling visualization of mycobacterial granulomas and host response without sectioning.

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