Subject collection: Tools and Resources for Mouse Studies
- Modelling epilepsy in the mouse: challenges and solutions
Summary: This Review discusses the challenges of modelling epilepsy in mice, a condition in which the outward manifestation of the disorder appears only sporadically, and reviews possible solutions encompassing both genetic and induced models.
- Mutant non-coding RNA resource in mouse embryonic stem cells
Summary: Analysis of a large library of mouse embryonic stem cell lines with gene trap insertions revealed mutations in 2202 unique non-coding RNA genes, which will significantly contribute to the functional annotation of non-coding RNA genes.
- Mouse models of myocardial infarction: comparing permanent ligation and ischaemia-reperfusion
Summary: Permanent ligation and ischaemia-reperfusion are common models for studying myocardial infarction. Here, we summarise the differences between them and outline the strengths of each in addressing distinct questions related to the human condition.
- A mouse SWATH-mass spectrometry reference spectral library enables deconvolution of species-specific proteomic alterations in human tumour xenografts
Editor's choice: This paper presents the MouseRefSWATH mouse reference spectral library as a standardized community resource for SWATH-mass spectrometry studies and the XenoSWATH pipeline for species-specific deconvolution of human xenograft proteomic data.
- Mouse models for muscular dystrophies: an overview
Summary: This Review and its accompanying comprehensive table summarize the most commonly used mouse models for a subset of highly studied muscular dystrophies.
- Predicting human disease mutations and identifying drug targets from mouse gene knockout phenotyping campaigns
Summary: Large-scale, focused phenotyping campaigns provide data for thousands of mutant mouse genes, yielding key information for understanding rare human diseases and for developing novel drug therapies.
- Generating mouse models for biomedical research: technological advances
Summary: Newer molecular technologies to precisely and efficiently manipulate the mammalian genome are enabling the production of more scientifically valuable animal models.
- Pathogenic and non-pathogenic Escherichia coli colonization and host inflammatory response in a defined microbiota mouse model
Summary: Mice harboring a defined microbiota of the altered Schaedler flora were identified as a reliable tool to assess prolonged Escherichia coli intestinal colonization and activation of the host inflammatory response.
- Living inside the box: environmental effects on mouse models of human disease
Summary: The utility of mice as models of human disease is often questioned because they live in a controlled laboratory environment, unlike humans. The authors compare the environments of humans and mice, and find parallels, suggesting that they are not so different. Understanding how mouse and human environments affect phenotypes is critical for the development of models of human disease.
- Growth of human breast cancers in Peromyscus
Summary: Outbred stocks of Peromyscus californicus (California mice), upon pharmacological immunosuppression, provide an alternative to conventional inbred mice models, and can support the growth of hormone-insensitive and hormone-sensitive human breast cancers.