Subject collection: Metabolic Disorders
- Human umbilical cord matrix-derived stem cells exert trophic effects on β-cell survival in diabetic rats and isolated islets
Summary: The newly identified paracrine role of umbilical cord stem cells highlights their therapeutic utilities to treat not only the autoimmune-mediated type 1 diabetes but also type 2 diabetes.
- Albumin stimulates renal tubular inflammation through an HSP70-TLR4 axis in mice with early diabetic nephropathy
Summary: Activation of the HSP70-TLR4 axis by albumin in the tubular cell induces tubular inflammation and injury.
- A mitochondrial therapeutic reverses visual decline in mouse models of diabetes
Summary: Visual decline in mouse models of diabetes is reversed, independently of treating other disease symptoms, by treatment with MTP-131, a water-soluble peptide that selectively targets cardiolipin and improves mitochondrial bioenergetics.
- Chronic administration of recombinant IL-6 upregulates lipogenic enzyme expression and aggravates high-fat-diet-induced steatosis in IL-6-deficient mice
Summary: The administration of rIL-6 might contribute to the aggravation of fatty liver disease through increasing lipogenesis in HFD-induced obesity.
- The lysyl oxidase inhibitor β-aminopropionitrile reduces body weight gain and improves the metabolic profile in diet-induced obesity in rats
Highlighted Article: Lysyl oxidase (LOX) could play a role in the metabolic dysfunction induced by obesity, and consequently the inhibition of LOX activity could be a valuable strategy to ameliorate obesity-related metabolic disturbances.