Subject collection: Metabolic Disorders
- A model of type 2 diabetes in the guinea pig using sequential diet-induced glucose intolerance and streptozotocin treatment
Summary: The guinea pig can act as a tool for investigators interested in the translational manifestations of diabetes using new methods for induction of type 2 diabetes.
- Preclinical models for obesity research
Summary: We review genetic models of obesity, their optogenetic and chemogenetic successors, and the use of dietary manipulations and meal-feeding regimes.
- Insulin receptor isoform A ameliorates long-term glucose intolerance in diabetic mice
Summary: The specific hepatic expression of insulin receptor isoform A, but not isoform B, is able to revert, in the long term, the global glucose intolerance observed in diabetic mice.
- Photoperiod induced obesity in the Brandt's vole (Lasiopodomys brandtii): a model of ‘healthy obesity’?
Summary: Obesity induced by long-day photoperiod in voles is not accompanied by impaired glucose tolerance or insulin sensitivity and might be a useful model of ‘healthy obesity’.
- Acute and long-term outcomes in a Drosophila melanogaster model of classic galactosemia occur independently of galactose-1-phosphate accumulation
Summary: In a GALT-deficient Drosophila model of classic galactosemia, Gal-1P accumulation is not required for compromised larval survival following galactose exposure or adult movement and fecundity phenotypes.
- Poor maternal nutrition and accelerated postnatal growth induces an accelerated aging phenotype and oxidative stress in skeletal muscle of male rats
Summary: Muscle of ‘developmentally programmed’ rat offspring demonstrated accelerated aging and oxidative stress, which could explain why some individuals are at greater risk of developing age-associated muscular dysfunction than others.
- Identification of a nutrient-sensing transcriptional network in monocytes by using inbred rat models on a cafeteria diet
Summary: Feeding with a cafeteria diet (CAF) is a reproducible model of human metabolic syndrome in the rat. By using inbred rat models of nutrigenomics, we have studied the effect of CAF on monocyte transcriptome.
- Seeking out the sweet spot in cancer therapeutics: an interview with Lewis Cantley
Summary: We spoke to Lewis Cantley about his career path and the story behind some of his key breakthroughs, including discovery of the phosphoinositide 3-kinase signaling pathway and insights into the role of dysregulated metabolism in cancer.
- The interplay between obesity and cancer: a fly view
Summary: This Review highlights a Drosophila model of diet-induced obesity and cancer, and how these two models are combined to study the interplay between obesity and cancer.
- A new glucocerebrosidase-deficient neuronal cell model provides a tool to probe pathophysiology and therapeutics for Gaucher disease
Summary: This work describes the generation of a novel immortalized glucocerebrosidase-deficient neuronal cell model with utility for pathophysiology research and therapeutic development in Gaucher disease.