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Subject collection: Metabolic Disorders

  • RESEARCH ARTICLE
    Genetic, physiological and comparative genomic studies of hypertension and insulin resistance in the spontaneously hypertensive rat
    Philip M. Coan, Oliver Hummel, Ana Garcia Diaz, Marjorie Barrier, Neza Alfazema, Penny J. Norsworthy, Michal Pravenec, Enrico Petretto, Norbert Hübner, Timothy J. Aitman
    Disease Models & Mechanisms 2017 10: 297-306; doi: 10.1242/dmm.026716

    Summary: Comparative genome analyses identify candidate genes for hypertension and insulin resistance on rat chromosomes 12 and 16, and marked enrichment of insulin resistance genes in the syntenic regions of the human genome.

  • RESEARCH ARTICLE
    Diabetic polyneuropathy, sensory neurons, nuclear structure and spliceosome alterations: a role for CWC22
    Masaki Kobayashi, Ambika Chandrasekhar, Chu Cheng, Jose A. Martinez, Hilarie Ng, Cristiane de la Hoz, Douglas W. Zochodne
    Disease Models & Mechanisms 2017 10: 215-224; doi: 10.1242/dmm.028225

    Summary: Subtle alterations in spliceosome structure and function in diabetic sensory neurons, including dysregulated Cajal bodies and CWC22 overexpression, might promote the development of diabetic sensory polyneuropathy.

  • RESEARCH ARTICLE
    Intestinal epithelial cell caveolin 1 regulates fatty acid and lipoprotein cholesterol plasma levels
    Jessica P. Otis, Meng-Chieh Shen, Vanessa Quinlivan, Jennifer L. Anderson, Steven A. Farber
    Disease Models & Mechanisms 2017 10: 283-295; doi: 10.1242/dmm.027300

    Summary: Caveolin 1, which forms caveolae, localizes to the basolateral membrane of zebrafish intestinal epithelial cells and regulates circulating murine fatty acid and lipoprotein cholesterol levels.

  • RESEARCH ARTICLE
    A model of type 2 diabetes in the guinea pig using sequential diet-induced glucose intolerance and streptozotocin treatment
    Brendan K. Podell, David F. Ackart, Michael A. Richardson, James E. DiLisio, Bruce Pulford, Randall J. Basaraba
    Disease Models & Mechanisms 2017 10: 151-162; doi: 10.1242/dmm.025593

    Summary: The guinea pig can act as a tool for investigators interested in the translational manifestations of diabetes using new methods for induction of type 2 diabetes.

  • REVIEW
    Preclinical models for obesity research
    Perry Barrett, Julian G. Mercer, Peter J. Morgan
    Disease Models & Mechanisms 2016 9: 1245-1255; doi: 10.1242/dmm.026443

    Summary: We review genetic models of obesity, their optogenetic and chemogenetic successors, and the use of dietary manipulations and meal-feeding regimes.

  • RESEARCH ARTICLE
    Insulin receptor isoform A ameliorates long-term glucose intolerance in diabetic mice
    Sabela Diaz-Castroverde, Almudena Gómez-Hernández, Silvia Fernández, Gema García-Gómez, Marianna Di Scala, Gloria González-Aseguinolaza, Elisa Fernández-Millán, Águeda González-Rodríguez, María García-Bravo, Pierre Chambon, Carmen Álvarez, Liliana Perdomo, Nuria Beneit, Oscar Escribano, Manuel Benito
    Disease Models & Mechanisms 2016 9: 1271-1281; doi: 10.1242/dmm.025288

    Summary: The specific hepatic expression of insulin receptor isoform A, but not isoform B, is able to revert, in the long term, the global glucose intolerance observed in diabetic mice.

  • RESEARCH ARTICLE
    Photoperiod induced obesity in the Brandt's vole (Lasiopodomys brandtii): a model of ‘healthy obesity’?
    Xin-Yu Liu, Deng-Bao Yang, Yan-Chao Xu, Marianne O. L. Gronning, Fang Zhang, De-Hua Wang, John R. Speakman
    Disease Models & Mechanisms 2016 9: 1357-1366; doi: 10.1242/dmm.026070

    Summary: Obesity induced by long-day photoperiod in voles is not accompanied by impaired glucose tolerance or insulin sensitivity and might be a useful model of ‘healthy obesity’.

  • RESEARCH ARTICLE
    Acute and long-term outcomes in a Drosophila melanogaster model of classic galactosemia occur independently of galactose-1-phosphate accumulation
    Jennifer M. I. Daenzer, Patricia P. Jumbo-Lucioni, Marquise L. Hopson, Kerry R. Garza, Emily L. Ryan, Judith L. Fridovich-Keil
    Disease Models & Mechanisms 2016 9: 1375-1382; doi: 10.1242/dmm.022988

    Summary: In a GALT-deficient Drosophila model of classic galactosemia, Gal-1P accumulation is not required for compromised larval survival following galactose exposure or adult movement and fecundity phenotypes.

  • RESEARCH ARTICLE
    Poor maternal nutrition and accelerated postnatal growth induces an accelerated aging phenotype and oxidative stress in skeletal muscle of male rats
    Jane L. Tarry-Adkins, Denise S. Fernandez-Twinn, Jian Hua Chen, Iain P. Hargreaves, Viruna Neergheen, Catherine E. Aiken, Susan E. Ozanne
    Disease Models & Mechanisms 2016 9: 1221-1229; doi: 10.1242/dmm.026591

    Summary: Muscle of ‘developmentally programmed’ rat offspring demonstrated accelerated aging and oxidative stress, which could explain why some individuals are at greater risk of developing age-associated muscular dysfunction than others.

  • RESOURCE ARTICLE
    Identification of a nutrient-sensing transcriptional network in monocytes by using inbred rat models on a cafeteria diet
    Neus Martínez-Micaelo, Noemi González-Abuín, Ximena Terra, Ana Ardévol, Montserrat Pinent, Enrico Petretto, Jacques Behmoaras, Mayte Blay
    Disease Models & Mechanisms 2016 9: 1231-1239; doi: 10.1242/dmm.025528

    Summary: Feeding with a cafeteria diet (CAF) is a reproducible model of human metabolic syndrome in the rat. By using inbred rat models of nutrigenomics, we have studied the effect of CAF on monocyte transcriptome.

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