Subject collection: Metabolic Disorders
- Poor maternal nutrition and accelerated postnatal growth induces an accelerated aging phenotype and oxidative stress in skeletal muscle of male rats
Summary: Muscle of ‘developmentally programmed’ rat offspring demonstrated accelerated aging and oxidative stress, which could explain why some individuals are at greater risk of developing age-associated muscular dysfunction than others.
- Identification of a nutrient-sensing transcriptional network in monocytes by using inbred rat models on a cafeteria diet
Summary: Feeding with a cafeteria diet (CAF) is a reproducible model of human metabolic syndrome in the rat. By using inbred rat models of nutrigenomics, we have studied the effect of CAF on monocyte transcriptome.
- Seeking out the sweet spot in cancer therapeutics: an interview with Lewis Cantley
Summary: We spoke to Lewis Cantley about his career path and the story behind some of his key breakthroughs, including discovery of the phosphoinositide 3-kinase signaling pathway and insights into the role of dysregulated metabolism in cancer.
- The interplay between obesity and cancer: a fly view
Summary: This Review highlights a Drosophila model of diet-induced obesity and cancer, and how these two models are combined to study the interplay between obesity and cancer.
- A new glucocerebrosidase-deficient neuronal cell model provides a tool to probe pathophysiology and therapeutics for Gaucher disease
Summary: This work describes the generation of a novel immortalized glucocerebrosidase-deficient neuronal cell model with utility for pathophysiology research and therapeutic development in Gaucher disease.
- Increased oxidative stress and apoptosis in the hypothalamus of diabetic male mice in the insulin receptor substrate-2 knockout model
Summary: Only IRS2-deficient male mice that become diabetic show apoptosis in the hypothalamus and this is associated with an increase in oxidative stress and inflammatory signals. Controlling inflammation and oxidative stress could prevent diabetes-induced brain injury.
- Using Drosophila to discover mechanisms underlying type 2 diabetes
Drosophila Collection: Studies in Drosophila hold the potential to transform our understanding of the genetics of diabetes. We review important findings and provide a framework for diabetes gene discovery in the fly.
- 5-HT2A and 5-HT2C receptors as hypothalamic targets of developmental programming in male rats
Summary: Maternal protein restriction increases fetal brain 5-HT and might contribute to changes in production and function of hypothalamic 5-HT2C and 5-HT2A receptors in the offspring later in life.
- A new gestational diabetes mellitus model: hyperglycemia-induced eye malformation via inhibition of Pax6 in the chick embryo
Summary: Hyperglycemia inhibited Pax6 via oxidative stress and impaired eye development in the chick embryo, a new gestational diabetes mellitus model.
- The cannabinoid CB1 receptor and mTORC1 signalling pathways interact to modulate glucose homeostasis in mice
Summary: Evidence supporting a functional interaction between the endocannabinoid system and the mTORC1 pathway within the endocrine pancreas, which could have implications for the development of new therapeutic approaches for diabetes.