Subject collection: Metabolic Disorders
- Genetic, physiological and comparative genomic studies of hypertension and insulin resistance in the spontaneously hypertensive rat
Summary: Comparative genome analyses identify candidate genes for hypertension and insulin resistance on rat chromosomes 12 and 16, and marked enrichment of insulin resistance genes in the syntenic regions of the human genome.
- Diabetic polyneuropathy, sensory neurons, nuclear structure and spliceosome alterations: a role for CWC22
Summary: Subtle alterations in spliceosome structure and function in diabetic sensory neurons, including dysregulated Cajal bodies and CWC22 overexpression, might promote the development of diabetic sensory polyneuropathy.
- Intestinal epithelial cell caveolin 1 regulates fatty acid and lipoprotein cholesterol plasma levels
Summary: Caveolin 1, which forms caveolae, localizes to the basolateral membrane of zebrafish intestinal epithelial cells and regulates circulating murine fatty acid and lipoprotein cholesterol levels.
- A model of type 2 diabetes in the guinea pig using sequential diet-induced glucose intolerance and streptozotocin treatment
Summary: The guinea pig can act as a tool for investigators interested in the translational manifestations of diabetes using new methods for induction of type 2 diabetes.
- Preclinical models for obesity research
Summary: We review genetic models of obesity, their optogenetic and chemogenetic successors, and the use of dietary manipulations and meal-feeding regimes.
- Insulin receptor isoform A ameliorates long-term glucose intolerance in diabetic mice
Summary: The specific hepatic expression of insulin receptor isoform A, but not isoform B, is able to revert, in the long term, the global glucose intolerance observed in diabetic mice.
- Photoperiod induced obesity in the Brandt's vole (Lasiopodomys brandtii): a model of ‘healthy obesity’?
Summary: Obesity induced by long-day photoperiod in voles is not accompanied by impaired glucose tolerance or insulin sensitivity and might be a useful model of ‘healthy obesity’.
- Acute and long-term outcomes in a Drosophila melanogaster model of classic galactosemia occur independently of galactose-1-phosphate accumulation
Summary: In a GALT-deficient Drosophila model of classic galactosemia, Gal-1P accumulation is not required for compromised larval survival following galactose exposure or adult movement and fecundity phenotypes.
- Poor maternal nutrition and accelerated postnatal growth induces an accelerated aging phenotype and oxidative stress in skeletal muscle of male rats
Summary: Muscle of ‘developmentally programmed’ rat offspring demonstrated accelerated aging and oxidative stress, which could explain why some individuals are at greater risk of developing age-associated muscular dysfunction than others.
- Identification of a nutrient-sensing transcriptional network in monocytes by using inbred rat models on a cafeteria diet
Summary: Feeding with a cafeteria diet (CAF) is a reproducible model of human metabolic syndrome in the rat. By using inbred rat models of nutrigenomics, we have studied the effect of CAF on monocyte transcriptome.