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Subject collection: Metabolic Disorders

  • RESEARCH ARTICLE
    Mild maternal hyperglycemia in INSC93S transgenic pigs causes impaired glucose tolerance and metabolic alterations in neonatal offspring
    Simone Renner, Ana Sofia Martins, Elisabeth Streckel, Christina Braun-Reichhart, Mattias Backman, Cornelia Prehn, Nikolai Klymiuk, Andrea Bähr, Andreas Blutke, Christina Landbrecht-Schessl, Annegret Wünsch, Barbara Kessler, Mayuko Kurome, Arne Hinrichs, Sietse-Jan Koopmans, Stefan Krebs, Elisabeth Kemter, Birgit Rathkolb, Hiroshi Nagashima, Helmut Blum, Mathias Ritzmann, Rüdiger Wanke, Bernhard Aigner, Jerzy Adamski, Martin Hrabě de Angelis, Eckhard Wolf
    Disease Models & Mechanisms 2019 12: dmm039156 doi: 10.1242/dmm.039156 Published 12 August 2019

    Editor's choice: Mild maternal hyperglycemia causes impaired glucose tolerance and metabolic alterations in wild-type neonatal offspring of INSC93S transgenic pigs, a novel large animal model for mutant INS gene-induced diabetes of youth (MIDY).

  • RESEARCH ARTICLE
    Conserved properties of genetic architecture of renal and fat transcriptomes in rat models of insulin resistance
    Georg W. Otto, Pamela J. Kaisaki, Francois Brial, Aurélie Le Lay, Jean-Baptiste Cazier, Richard Mott, Dominique Gauguier
    Disease Models & Mechanisms 2019 12: dmm038539 doi: 10.1242/dmm.038539 Published 15 July 2019

    Summary: Kidney and fat expression QTL mapping in rat models of spontaneously occurring insulin resistance associated with either diabetes or hypertension reveals conserved gene expression regulation, suggesting shared aetiology of disease phenotypes.

  • RESEARCH ARTICLE
    Beneficial effects of exercise on gut microbiota functionality and barrier integrity, and gut-liver crosstalk in an in vivo model of early obesity and non-alcoholic fatty liver disease
    Sara Carbajo-Pescador, David Porras, María Victoria García-Mediavilla, Susana Martínez-Flórez, María Juarez-Fernández, María José Cuevas, José Luis Mauriz, Javier González-Gallego, Esther Nistal, Sonia Sánchez-Campos
    Disease Models & Mechanisms 2019 12: dmm039206 doi: 10.1242/dmm.039206 Published 30 April 2019

    Summary: The beneficial effects of exercise against diet-induced early obesity and NAFLD are mediated by its capacity to modulate intestinal microbiota composition and functionality, restore lipid metabolism and prevent disruption of the gut-liver axis.

  • RESEARCH ARTICLE
    Differential regulation of the unfolded protein response in outbred deer mice and susceptibility to metabolic disease
    Amanda Havighorst, Youwen Zhang, Elena Farmaki, Vimala Kaza, Ioulia Chatzistamou, Hippokratis Kiaris
    Disease Models & Mechanisms 2019 12: dmm037242 doi: 10.1242/dmm.037242 Published 27 February 2019

    Summary: By using genetically diverse deer mice, we show that the expression of different chaperones is highly coordinated in individual animals and its profile predicts the onset of metabolic pathology.

  • RESEARCH ARTICLE
    Liver-specific insulin receptor isoform A expression enhances hepatic glucose uptake and ameliorates liver steatosis in a mouse model of diet-induced obesity
    Andrea Raposo Lopez-Pastor, Almudena Gomez-Hernandez, Sabela Diaz-Castroverde, Gloria Gonzalez-Aseguinolaza, Agueda Gonzalez-Rodriguez, Gema Garcia, Silvia Fernandez, Oscar Escribano, Manuel Benito
    Disease Models & Mechanisms 2019 12: dmm036186 doi: 10.1242/dmm.036186 Published 7 February 2019

    Summary: Adeno-associated-virus-mediated gene therapy for insulin receptor isoform A expression in the liver improves glucose disposal and alleviates lipid accumulation in wild-type mice under a high-fat diet.

  • RESOURCE ARTICLE
    Juvenile murine models of prediabetes and type 2 diabetes develop neuropathy
    Phillipe D. O'Brien, Lucy M. Hinder, Amy E. Rumora, John M. Hayes, Jacqueline R. Dauch, Carey Backus, Faye E. Mendelson, Eva L. Feldman
    Disease Models & Mechanisms 2018 11: dmm037374 doi: 10.1242/dmm.037374 Published 18 December 2018

    Summary: The mouse models described in this paper provide critical tools to better understand the underlying pathogenesis of prediabetic and diabetic neuropathy from youth to adulthood.

  • RESEARCH ARTICLE
    Targeting ulcerative colitis by suppressing glucose uptake with ritonavir
    Henrika Jodeleit, Omar Al-Amodi, Janina Caesar, Christina Villarroel Aguilera, Lesca Holdt, Roswitha Gropp, Florian Beigel, Matthias Siebeck
    Disease Models & Mechanisms 2018 11: dmm036210 doi: 10.1242/dmm.036210 Published 21 November 2018

    Summary: Insights into immuno-metabolism open up new avenues for therapeutic intervention. The study presented here suggests that inhibition of glucose suppresses inflammation in a mouse model of ulcerative colitis.

  • RESEARCH ARTICLE
    A novel mutation in the NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 4 (Ndufa4) gene links mitochondrial dysfunction to the development of diabetes in a rodent model
    Chana Yagil, Ronen Varadi-Levi, Yoram Yagil
    Disease Models & Mechanisms 2018 11: dmm036699 doi: 10.1242/dmm.036699 Published 20 November 2018

    Summary: Here, we report, for the first time, a major inherited mutation in a diabetes-prone animal model that adversely affects mitochondrial function and leads, through oxidative stress, to the development of diet-induced diabetes.

  • RESEARCH ARTICLE
    One month of hyperglycemia alters spectral responses of the zebrafish photopic electroretinogram
    Zaid Tanvir, Ralph F. Nelson, Kathleen DeCicco-Skinner, Victoria P. Connaughton
    Disease Models & Mechanisms 2018 11: dmm035220 doi: 10.1242/dmm.035220 Published 22 October 2018

    Summary: Zebrafish can be used to examine diabetic complications, including vision loss. Here, in zebrafish, we show that prolonged (4 week) hyperglycemia causes an inflammatory response associated with functional deficits localized to specific cone types.

  • RESEARCH ARTICLE
    A nonalcoholic fatty liver disease model in human induced pluripotent stem cell-derived hepatocytes, created by endoplasmic reticulum stress-induced steatosis
    Maddalena Parafati, R. Jason Kirby, Sepideh Khorasanizadeh, Fraydoon Rastinejad, Siobhan Malany
    Disease Models & Mechanisms 2018 11: dmm033530 doi: 10.1242/dmm.033530 Published 25 September 2018

    Summary: Our study demonstrates expanded use of human induced pluripotent stem cell-derived hepatocytes for molecular studies and drug screening, to evaluate new therapeutics with an antisteatotic mechanism of action for nonalcoholic fatty liver disease.

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