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Subject collection: Metabolic Disorders

  • RESEARCH ARTICLE
    Sensory neuron cultures derived from adult db/db mice as a simplified model to study type-2 diabetes-associated axonal regeneration defects
    Cristian De Gregorio, Fernando Ezquer
    Disease Models & Mechanisms 2021 14: dmm046334 doi: 10.1242/dmm.046334 Published 22 January 2021

    Summary: Morphological characterization of a model for evaluating neuritic regeneration in vitro in dorsal root ganglion primary neurons derived from type-2 diabetic mice with an advanced stage of diabetic neuropathy.

  • RESEARCH ARTICLE
    3D quantification of changes in pancreatic islets in mouse models of diabetes type I and II
    Urmas Roostalu, Jacob Lercke Skytte, Casper Gravesen Salinas, Thomas Klein, Niels Vrang, Jacob Jelsing, Jacob Hecksher-Sørensen
    Disease Models & Mechanisms 2020 13: dmm045351 doi: 10.1242/dmm.045351 Published 18 December 2020

    Summary: We report a 3D quantitative imaging platform (using light-sheet fluorescence microscopy) that can reveal changes in beta cell volume and proliferation, and leukocyte infiltration in pancreata in mouse models of diabetes.

  • RESEARCH ARTICLE
    A comprehensive study of phospholipid fatty acid rearrangements in metabolic syndrome: correlations with organ dysfunction
    Amélie Bacle, Linette Kadri, Spiro Khoury, Romain Ferru-Clément, Jean-François Faivre, Christian Cognard, Jocelyn Bescond, Amandine Krzesiak, Hugo Contzler, Nathalie Delpech, Jenny Colas, Clarisse Vandebrouck, Stéphane Sébille, Thierry Ferreira
    Disease Models & Mechanisms 2020 13: dmm043927 doi: 10.1242/dmm.043927 Published 15 June 2020

    Summary: In rats, a high-fat diet induces the selective distribution of fatty acids within phosphatidylcholine in the liver and muscles, in a manner that correlates with organ dysfunction. The cardiovascular system appears to be protected under these conditions.

  • RESEARCH ARTICLE
    Novel defatting strategies reduce lipid accumulation in primary human culture models of liver steatosis
    Lynda Aoudjehane, Jérémie Gautheron, Wilfried Le Goff, Claire Goumard, Julia Gilaizeau, Chan Sonavine Nget, Eric Savier, Muhammad Atif, Philippe Lesnik, Romain Morichon, Yves Chrétien, Yvon Calmus, Olivier Scatton, Chantal Housset, Filomena Conti
    Disease Models & Mechanisms 2020 13: dmm042663 doi: 10.1242/dmm.042663 Published 29 April 2020

    Summary: This study describes a defatting cocktail that has been proven to function in three relevant steatotic human culture models without cytotoxicity, and which could be employed in the reduction of steatosis in donor livers during liver transplantation.

  • RESEARCH ARTICLE
    Familial hypercholesterolemia class II low-density lipoprotein receptor response to statin treatment
    Linda Omer, Lubna Hindi, Giuseppe Militello, Katlin B. Stivers, Kenneth C. Tien, Nolan L. Boyd
    Disease Models & Mechanisms 2020 13: dmm042911 doi: 10.1242/dmm.042911 Published 6 April 2020

    Editor's choice: Statin-induced upregulation of class II mutant LDLR does not cause acute endoplasmic reticulum (ER) stress and unfolded protein response induction, in spite of misfolded LDLR protein accumulation in the ER.

  • RESEARCH ARTICLE
    Integrated lipidomic and transcriptomic analyses identify altered nerve triglycerides in mouse models of prediabetes and type 2 diabetes
    Phillipe D. O'Brien, Kai Guo, Stephanie A. Eid, Amy E. Rumora, Lucy M. Hinder, John M. Hayes, Faye E. Mendelson, Junguk Hur, Eva L. Feldman
    Disease Models & Mechanisms 2020 13: dmm042101 doi: 10.1242/dmm.042101 Published 24 January 2020

    Summary: Mouse models of prediabetes and type 2 diabetes that develop peripheral neuropathy display increased levels of nerve triglycerides, which return to normal upon dietary reversal, suggesting that altered lipids are involved in disease.

  • RESEARCH ARTICLE
    Cell-specific and athero-protective roles for RIPK3 in a murine model of atherosclerosis
    Sarah Colijn, Vijay Muthukumar, Jun Xie, Siqi Gao, Courtney T. Griffin
    Disease Models & Mechanisms 2020 13: dmm041962 doi: 10.1242/dmm.041962 Published 24 January 2020

    Summary: This study reports that RIPK3 in macrophages and endothelial cells protects against atherosclerosis progression in mice, providing novel information about unexpected roles for RIPK3 in an inflammatory vascular disease.

  • RESEARCH ARTICLE
    Ablation of Bscl2/seipin in hepatocytes does not cause metabolic dysfunction in congenital generalised lipodystrophy
    George D. Mcilroy, Sharon E. Mitchell, Weiping Han, Mirela Delibegović, Justin J. Rochford
    Disease Models & Mechanisms 2020 13: dmm042655 doi: 10.1242/dmm.042655 Published 17 January 2020

    Editor's choice: Hepatic Bscl2 ablation in adipose tissue-specific Bscl2 knockout mice does not cause metabolic dysfunction. CRISPR/Cas9 genome editing reveals that seipin does not play a cell-autonomous role in regulating hepatocyte lipid accumulation.

  • RESEARCH ARTICLE
    Sodium nitroprusside prevents the detrimental effects of glucose on the neurovascular unit and behaviour in zebrafish
    Karishma Chhabria, Avgoustinos Vouros, Caroline Gray, Ryan B. MacDonald, Zhen Jiang, Robert Neil Wilkinson, Karen Plant, Eleni Vasilaki, Clare Howarth, Timothy J. A. Chico
    Disease Models & Mechanisms 2019 12: dmm039867 doi: 10.1242/dmm.039867 Published 25 September 2019

    Summary: Diabetes is associated with vascular and neurological impairments. The authors show that an NO donor ameliorates the glucose-exposure-induced dysfunction in the tectal neurovascular unit and whole-organism behaviour.

  • RESEARCH ARTICLE
    A new mouse model of GLUT1 deficiency syndrome exhibits abnormal sleep-wake patterns and alterations of glucose kinetics in the brain
    Tamio Furuse, Hiroshi Mizuma, Yuuki Hirose, Tomoko Kushida, Ikuko Yamada, Ikuo Miura, Hiroshi Masuya, Hiromasa Funato, Masashi Yanagisawa, Hirotaka Onoe, Shigeharu Wakana
    Disease Models & Mechanisms 2019 12: dmm038828 doi: 10.1242/dmm.038828 Published 12 September 2019

    Summary: New phenotypes are revealed by a GLUT1 deficiency mutant mouse model carrying a missense mutation in Glut1.

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