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Subject collection: Cancer metabolism

  • RESEARCH ARTICLE
    Teleological role of L-2-hydroxyglutarate dehydrogenase in the kidney
    Garrett Brinkley, Hyeyoung Nam, Eunhee Shim, Richard Kirkman, Anirban Kundu, Suman Karki, Yasaman Heidarian, Jason M. Tennessen, Juan Liu, Jason W. Locasale, Tao Guo, Shi Wei, Jennifer Gordetsky, Teresa L. Johnson-Pais, Devin Absher, Dinesh Rakheja, Anil K. Challa, Sunil Sudarshan
    Disease Models & Mechanisms 2020 13: dmm045898 doi: 10.1242/dmm.045898 Published 27 November 2020

    Summary: Using a murine knockout model and analysis of human cells, we demonstrate a novel role for L-2-hydroxyglutarate dehydrogenase in the kidney as well as new insight into the mechanisms that regulate expression of this enzyme.

  • RESEARCH ARTICLE
    The SDHB Arg230His mutation causing familial paraganglioma alters glycolysis in a new Caenorhabditis elegans model
    Éva Saskői, Zoltán Hujber, Gábor Nyírő, István Likó, Barbara Mátyási, Gábor Petővári, Katalin Mészáros, Attila L. Kovács, László Patthy, Shreyas Supekar, Hao Fan, Gergely Sváb, László Tretter, Arunabh Sarkar, Aamir Nazir, Anna Sebestyén, Attila Patócs, Anil Mehta, Krisztina Takács-Vellai
    Disease Models & Mechanisms 2020 13: dmm044925 doi: 10.1242/dmm.044925 Published 15 October 2020

    Editor’s choice: Heritable pheochromocytoma/paraganglioma follows the Arg230His missense mutation in SDHB in mitochondrial complex II. By mutating this highly conserved ortholog in C. elegans, we generated a tractable phenotype.

  • RESEARCH ARTICLE
    A lineage-tracing tool to map the fate of hypoxic tumour cells
    Jenny A. F. Vermeer, Jonathan Ient, Bostjan Markelc, Jakob Kaeppler, Lydie M. O. Barbeau, Arjan J. Groot, Ruth J. Muschel, Marc A. Vooijs
    Disease Models & Mechanisms 2020 13: dmm044768 doi: 10.1242/dmm.044768 Published 30 July 2020

    Summary: Here, we developed and characterised a novel HIF-1α-Cre fusion protein to trace the progeny of hypoxic tumour cells in a temporal and spatially resolved manner using intravital microscopy.

  • RESEARCH ARTICLE
    HCT116 colorectal liver metastases exacerbate muscle wasting in a mouse model for the study of colorectal cancer cachexia
    Joshua R. Huot, Leah J. Novinger, Fabrizio Pin, Andrea Bonetto
    Disease Models & Mechanisms 2020 13: dmm043166 doi: 10.1242/dmm.043166 Published 24 January 2020

    Summary: Colorectal cancer-derived liver metastases exacerbate cachexia, in line with activation of STAT3 signaling. STAT3 inhibition may improve cancer-associated muscle wasting.

  • RESEARCH ARTICLE
    Leptin induces muscle wasting in a zebrafish kras-driven hepatocellular carcinoma (HCC) model
    Qiqi Yang, Chuan Yan, Xu Wang, Zhiyuan Gong
    Disease Models & Mechanisms 2019 12: dmm038240 doi: 10.1242/dmm.038240 Published 27 February 2019

    Summary: Through a zebrafish model, this study demonstrates that leptin plays an important role in cancer-induced muscle wasting and that the leptin pathway may be a therapeutic target in cancer cachexia.

  • RESEARCH ARTICLE
    A Drosophila model of combined D-2- and L-2-hydroxyglutaric aciduria reveals a mechanism linking mitochondrial citrate export with oncometabolite accumulation
    Hongde Li, Alexander J. Hurlburt, Jason M. Tennessen
    Disease Models & Mechanisms 2018 11: dmm035337 doi: 10.1242/dmm.035337 Published 21 September 2018

    Summary: This study reveals a mechanism that links export of mitochondrial citrate to accumulation of the oncometabolite L-2-hydroxyglutarate, suggesting a potential treatment for individuals with combined D-2- and L-2-hydroxyglutaric aciduria, a rare inborn error of metabolism.

  • EDITORIAL
    The big picture: exploring the metabolic cross-talk in cancer
    Almut Schulze, Mariia Yuneva
    Disease Models & Mechanisms 2018 11: dmm036673 doi: 10.1242/dmm.036673 Published 24 August 2018

    Summary: The guest editors of this Special Collection discuss recent advances in the field of cancer metabolism, as well as the challenges faced as this exciting research progresses.

  • REVIEW
    Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies
    Alexander Muir, Laura V. Danai, Matthew G. Vander Heiden
    Disease Models & Mechanisms 2018 11: dmm035758 doi: 10.1242/dmm.035758 Published 7 August 2018

    Summary: Here, we discuss the model systems for cancer metabolism studies and highlight their key strengths and pitfalls in addressing different questions, such as how the microenvironment affects cancer metabolism and response to therapy.

  • REVIEW
    Arginine and the metabolic regulation of nitric oxide synthesis in cancer
    Rom Keshet, Ayelet Erez
    Disease Models & Mechanisms 2018 11: dmm033332 doi: 10.1242/dmm.033332 Published 6 August 2018

    Summary: In this Review, the authors focus on the regulation of NO levels by the synthesis and availability of arginine, and on the implications of this metabolic regulation to cancer biology and therapy.

  • AT A GLANCE
    Immunometabolism in cancer at a glance
    Katrin Singer, Wan-Chen Cheng, Marina Kreutz, Ping-Chih Ho, Peter J. Siska
    Disease Models & Mechanisms 2018 11: dmm034272 doi: 10.1242/dmm.034272 Published 2 August 2018

    Summary: This ‘At a Glance’ review and accompanying poster address how tumors can negatively affect immune cells through depletion of critical nutrients or through production of toxic metabolic products.

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