Subject collection: Cancer metabolism
- HCT116 colorectal liver metastases exacerbate muscle wasting in a mouse model for the study of colorectal cancer cachexia
Summary: Colorectal cancer-derived liver metastases exacerbate cachexia, in line with activation of STAT3 signaling. STAT3 inhibition may improve cancer-associated muscle wasting.
- Leptin induces muscle wasting in a zebrafish kras-driven hepatocellular carcinoma (HCC) model
Summary: Through a zebrafish model, this study demonstrates that leptin plays an important role in cancer-induced muscle wasting and that the leptin pathway may be a therapeutic target in cancer cachexia.
- A Drosophila model of combined D-2- and L-2-hydroxyglutaric aciduria reveals a mechanism linking mitochondrial citrate export with oncometabolite accumulation
Summary: This study reveals a mechanism that links export of mitochondrial citrate to accumulation of the oncometabolite L-2-hydroxyglutarate, suggesting a potential treatment for individuals with combined D-2- and L-2-hydroxyglutaric aciduria, a rare inborn error of metabolism.
- The big picture: exploring the metabolic cross-talk in cancer
Summary: The guest editors of this Special Collection discuss recent advances in the field of cancer metabolism, as well as the challenges faced as this exciting research progresses.
- Microenvironmental regulation of cancer cell metabolism: implications for experimental design and translational studies
Summary: Here, we discuss the model systems for cancer metabolism studies and highlight their key strengths and pitfalls in addressing different questions, such as how the microenvironment affects cancer metabolism and response to therapy.
- Arginine and the metabolic regulation of nitric oxide synthesis in cancer
Summary: In this Review, the authors focus on the regulation of NO levels by the synthesis and availability of arginine, and on the implications of this metabolic regulation to cancer biology and therapy.
- Immunometabolism in cancer at a glance
Summary: This ‘At a Glance’ review and accompanying poster address how tumors can negatively affect immune cells through depletion of critical nutrients or through production of toxic metabolic products.
- Hidden features: exploring the non-canonical functions of metabolic enzymes
Summary: This Review summarizes recent findings about multifaceted metabolic enzymes with non-canonical activities outside their core biochemical functions, and how they may provide new therapeutic strategies for cancers.
- The metabolic axis of macrophage and immune cell polarization
Summary: Extracellular metabolites can mediate cell communication and change transcriptional and functional aspects of tumor and normal cells. This Review focuses on how these metabolic cues affect the immune system with a special focus on tumor-associated macrophages.