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Disease Models & Mechanisms (DMM) is an Open Access biomedical research journal focusing on the use of model systems to better understand, diagnose and treat human disease.
The primary aim of DMM is to promote human health by inspiring collaboration between basic and clinical researchers in translational science. The journal is committed to presenting rigorously peer-reviewed research that has significant translational impact. The interdisciplinary nature of DMM means that a diverse range of diseases, approaches and models fall within its broad scope. DMM is guided by an international team of expert research-active Editors, led by Monica Justice and Ross Cagan, and supported by an outstanding Editorial Advisory Board.
Editor's choice
In October's Editor's choice, Yamanouchi et al. describe a newly established rat model carrying in-frame mutations in the Dmd gene. The model exhibits the dystrophic phenotype and abnormal dystrophin expression profile, similar to patients with Becker muscular dystrophy.
Comparative analyses of temporal cohorts of the Ts65Dn mouse model of Down syndrome by Haydar and co-workers reveal phenotypic variability affecting neurodevelopment and learning and memory behaviors, calling into question the validity of this model.
New reviews from DMM
A Special Article from Martinez and colleagues discusses current model systems to study the novel coronavirus SARS-CoV-2, the pathogen that causes COVID-19.
Vaccine development for tuberculosis requires an understanding of neonatal and infant immunity. Gonzalez-Juarrero and colleagues review animal models of neonatal and infant immunity, and highlight the potential of piglets as important models for vaccine development.
Fibrodysplasia ossificans progressiva is a rare disease characterised by progressive heterotopic bone formation. Phil Ingham and colleagues present a comprehensive summary of the recent literature on this debilitating condition and discuss approaches to solving this clinical puzzle.
Call for Papers – The RAS Pathway
Highlighted articles
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Roberta Resaz, Davide Cangelosi, Martina Morini, Daniela Segalerba, Luca Mastracci, Federica Grillo, Maria Carla Bosco, Cristina Bottino, Irma Colombo, Alessandra Eva
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Estela Selma-Soriano, Beatriz Llamusi, Juan Manuel Fernández-Costa, Lauren Louise Ozimski, Rubén Artero, Josep Redón
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Tatianna Wai Ying Wong, Abdalla Ahmed, Grace Yang, Eleonora Maino, Sydney Steiman, Elzbieta Hyatt, Parry Chan, Kyle Lindsay, Nicole Wong, Diane Golebiowski, Joel Schneider, Paul Delgado-Olguín, Evgueni A. Ivakine, Ronald D. Cohn
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Jelmer Hoeksma, Gerard C. M. van der Zon, Peter ten Dijke, Jeroen den Hertog
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Patricia R. Shaw, Jenny A. Klein, Nadine M. Aziz, Tarik F. Haydar
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Naomi Teramoto, Hidetoshi Sugihara, Keitaro Yamanouchi, Katsuyuki Nakamura, Koichi Kimura, Tomoko Okano, Takanori Shiga, Taku Shirakawa, Masafumi Matsuo, Tetsuya Nagata, Masao Daimon, Takashi Matsuwaki, Masugi Nishihara
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Joshua C. Peterson, Lambertus J. Wisse, Valerie Wirokromo, Tessa van Herwaarden, Anke M. Smits, Adriana C. Gittenberger-de Groot, Marie-José T. H. Goumans, J. Conny VanMunsteren, Monique R. M. Jongbloed, Marco C. DeRuiter
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Shohei Yoshimoto, Junko Yoshizumi, Hiromasa Anzai, Koichiro Morishita, Kazuhiko Okamura, Akimitsu Hiraki, Shuichi Hashimoto
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Angelino T. Tromp, Yuxi Zhao, Ilse Jongerius, Erik C. J. M. Heezius, Pauline Abrial, Maartje Ruyken, Jos A. G. van Strijp, Carla J. C. de Haas, András N. Spaan, Kok P. M. van Kessel, Thomas Henry, Pieter-Jan A. Haas