Disease Models & Mechanisms (DMM) is an online Open Access journal focusing on the use of model systems to better understand, diagnose and treat human disease.
The primary aim of DMM is to promote human health by inspiring collaboration between basic and clinical researchers in translational science. The journal is committed to presenting rigorously peer-reviewed research that has significant translational impact. The interdisciplinary nature of DMM means that a diverse range of diseases, approaches and models fall within its broad scope. DMM is guided by an international team of expert research-active Editors, led by Monica Justice and Ross Cagan, and supported by an outstanding Editorial Advisory Board.
Editor's choice
Erika Bach and colleagues used Drosophila to demonstrate that Tip60, a lysine acetyltransferase, acts as a tumour suppressor in myeloproliferative neoplasms by repressing JAK/STAT signalling.
We also feature the Richtsmeier group's article describing how FGFR2 mutations contribute to structural malformations of the mandible in craniosynostosis syndromes.
Recent highlights
In their new review, the Schenck group discuss the exciting contributions that work in Drosophila is making to our understanding of intellectual disabilty and autism spectrum disorders.
Also in this issue, a special article by Robert Brommage, David Powell and Peter Vogel summarises two large-scale mouse phenotyping campaigns that have provided data on disease-relevant genes and facilitated drug discovery.
DMM Journal Meeting
Highlighted articles
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Sara Carbajo-Pescador, David Porras, María Victoria García-Mediavilla, Susana Martínez-Flórez, María Juarez-Fernández, María José Cuevas, José Luis Mauriz, Javier González-Gallego, Esther Nistal, Sonia Sánchez-Campos
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Evisa Gjini, Chang-Bin Jing, Ashley T. Nguyen, Deepak Reyon, Emma Gans, Michiel Kesarsing, Joshua Peterson, Olga Pozdnyakova, Scott J. Rodig, Marc R. Mansour, Keith Joung, A. Thomas Look
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Scott D. Collum, Jose G. Molina, Ankit Hanmandlu, Weizhen Bi, Mesias Pedroza, Tinne C. J. Mertens, Nancy Wareing, Wang Wei, Cory Wilson, Wenchao Sun, Jayakumar Rajadas, Paul L. Bollyky, Kemly M. Philip, Dewei Ren, Rajarajan A. Thandavarayan, Brian A. Bruckner, Yang Xia, Michael R. Blackburn, Harry Karmouty-Quintana
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Tongcui Jiang, Emily Handley, Mariana Brizuela, Edgar Dawkins, Katherine E. A. Lewis, Rosemary M. Clark, Tracey C. Dickson, Catherine A. Blizzard
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Tuba Sural-Fehr, Harinder Singh, Ludovico Cantuti-Catelvetri, Hongling Zhu, Michael S. Marshall, Rima Rebiai, Martin J. Jastrzebski, Maria I. Givogri, Mark M. Rasenick, Ernesto R. Bongarzone
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Hyun-Ju Cho, Jae-Geun Lee, Jong-Hwan Kim, Seon-Young Kim, Yang Hoon Huh, Hyo-Jeong Kim, Kyu-Sun Lee, Kweon Yu, Jeong-Soo Lee
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Nadine Apetz, Elena Kordys, Mascha Simon, Britta Mang, Markus Aswendt, Dirk Wiedermann, Bernd Neumaier, Alexander Drzezga, Lars Timmermann, Heike Endepols
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Yufei Xie, Sofie Tolmeijer, Jelle M. Oskam, Tijs Tonkens, Annemarie H. Meijer, Marcel J. M. Schaaf
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Susan M. Motch Perrine, Meng Wu, Nicholas B. Stephens, Divya Kriti, Harm van Bakel, Ethylin Wang Jabs, Joan T. Richtsmeier
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Alessandro A. Bailetti, Lenny J. Negrón-Piñeiro, Vishal Dhruva, Sneh Harsh, Sean Lu, Aisha Bosula, Erika A. Bach