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Disease Models & Mechanisms (DMM) is an Open Access journal focusing on the use of model systems to better understand, diagnose and treat human disease.
The primary aim of DMM is to promote human health by inspiring collaboration between basic and clinical researchers in translational science. The journal is committed to presenting rigorously peer-reviewed research that has significant translational impact. The interdisciplinary nature of DMM means that a diverse range of diseases, approaches and models fall within its broad scope. DMM is guided by an international team of expert research-active Editors, led by Monica Justice and Ross Cagan, and supported by an outstanding Editorial Advisory Board.
Our Special Issue - A Guide to Using Neuromuscular Disease Models for Basic and Preclinical Studies - is now available. Click here to read the latest papers.
Editor's choice
The Guest editors of our special issue highlight two Editors' choice articles:
1. Grunwald and colleagues used zebrafish to show that skeletal muscle development and function depends on both additive and combinatorial interactions between ryanodine receptors.
2. Claire Wood et al. demonstrate that the mdx:Cmah-/- mouse has limited utility for studying growth and skeletal development in Duchenne muscular dystrophy.
Recent highlights
A new At a Glance poster article by Morgan and Partridge describes the mechanisms of skeletal muscle development, growth and regeneration, and the implications of these processes for muscle diseases.
We also highlight A model for life interviews with Elizabeth McNally and Louis Kunkel, two pioneers in neuromuscular disease research, and our cover article by Demonbreun et al., which describes a new gene-edited mouse model of limb-girdle muscular dystrophy 2C.
New Special Issue
Highlighted articles
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Eric M. Clark, Hannah J. T. Nonarath, Jonathan R. Bostrom, Brian A. Link
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Guillermo Tarrasó, Alberto Real-Martinez, Marta Parés, Lídia Romero-Cortadellas, Laura Puigros, Laura Moya, Noemí de Luna, Astrid Brull, Miguel Angel Martín, Joaquin Arenas, Alejandro Lucia, Antoni L. Andreu, Jordi Barquinero, John Vissing, Thomas O. Krag, Tomàs Pinós
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Cathryn L. Ugalde, Sarah J. Annesley, Shane E. Gordon, Katelyn Mroczek, Matthew A. Perugini, Victoria A. Lawson, Paul R. Fisher, David I. Finkelstein, Andrew F. Hill
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George D. Mcilroy, Sharon E. Mitchell, Weiping Han, Mirela Delibegović, Justin J. Rochford
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Wedad Fallatah, Tara Smith, Wei Cui, Dushmanthi Jayasinghe, Erminia Di Pietro, Shawn A. Ritchie, Nancy Braverman
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Sarah Colijn, Vijay Muthukumar, Jun Xie, Siqi Gao, Courtney T. Griffin
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Joshua R. Huot, Leah J. Novinger, Fabrizio Pin, Andrea Bonetto