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DMM and the Board of The Company of Biologists are delighted to announce the appointment of Professor Elizabeth Patton (Edinburgh, UK) as the new Editor-in-Chief of DMM.
Find out more about the appointment. 

Disease Models & Mechanisms: 14 (2)

Archive

Disease Models & Mechanisms (DMM) is an Open Access biomedical research journal focusing on the use of model systems to better understand, diagnose and treat human disease.

The primary aim of DMM is to promote human health by inspiring collaboration between basic and clinical researchers in translational science. The journal is committed to presenting rigorously peer-reviewed research that has significant translational impact. The interdisciplinary nature of DMM means that a diverse range of diseases, approaches and models fall within its broad scope. DMM is guided by an international team of expert research-active Editors, led by Editor-in-Chief Elizabeth Patton and Deputy Editor-in-Chief Elaine Mardis, and supported by an outstanding Editorial Advisory Board.

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  • Accepted manuscripts
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  • Open Access

    Metabolomics and lipidomics in C. elegans using a single sample preparation

    Marte Molenaars, Bauke V. Schomakers, Hyung L. Elfrink, Arwen W. Gao, Martin A. T. Vervaart, Mia L. Pras-Raves, Angela C. Luyf, Reuben L. Smith, Mark G. Sterken, Jan E. Kammenga, Antoine H. C. van Kampen, Georges E. Janssens, Frédéric M. Vaz, Michel van Weeghel, Riekelt H. Houtkooper
    PDF
  • Open Access

    High dimensional immunotyping of tumors grown in obese and non-obese mice

    Cara E. Wogsland, Hilde E. Lien, Line Pedersen, Pahul Hanjra, Sturla M. Grondal, Rolf A. Brekken, James B. Lorens, Nils Halberg
    PDF
  • Open Access

    Hyperuricemia causes kidney damage by promoting autophagy and NLRP3-mediated inflammation in rats with urate oxidase deficiency

    Mian Wu, Yiwen Ma, Xiaoting Chen, Nan Liang, Shen Qu, Haibing Chen
    PDF
  • Open Access

    EZH2 is required for parathyroid and thymic development through differentiation of the third pharyngeal pouch endoderm

    Cinzia Caprio, Gabriella Lania, Marchesa Bilio, Rosa Ferrentino, Li Chen, Antonio Baldini
    PDF
  • Open Access

    High-dose vitamin B1 therapy prevents the development of experimental fatty liver driven by overnutrition

    Mugagga Kalyesubula, Ramgopal Mopuri, Jimmy Asiku, Alexander Rosov, Sara Yosefi, Nir Edery, Samuel Bocobza, Uzi Moallem, Hay Dvir
    PDF
See more accepted manuscripts...

Editor's choice

Ketan Patel and colleagues describe how even brief exposure to muscle-growth-promoting treatments exerts a long-term detrimental effect on the testes, and test promising therapeutics to mitigate this side-effect. 

Also in this issue, a Resource article by the Wurst group: an extensive library of long non-coding RNAs in murine embryonic stem cells to facilitate functional annotation.

 

New reviews from DMM

A new Review by Carole Guillonneau and team discusses how improved models of AIRE deficiency can lead to better therapies for patients with the ultra-rare autoimmune APECED disease.

Also in this issue, the Finck group reviews how optimising hyperoxia-induced models of bronchopulmonary dysplasia could help clinicians mitigate long-term lung dysfunction in patients.

Call for Papers – The RAS Pathway

Highlighted articles

  • Mutant non-coding RNA resource in mouse embryonic stem cells
    Jens Hansen, Harald von Melchner, Wolfgang Wurst
  • Disruption of a Hedgehog-Foxf1-Rspo2 signaling axis leads...
    Talia Nasr, Andrea M. Holderbaum, Praneet Chaturvedi, Kunal Agarwal, Jessica L. Kinney, Keziah Daniels, Stephen L. Trisno, Vladimir Ustiyan, John M. Shannon, James M. Wells, Debora Sinner, Vladimir V. Kalinichenko, Aaron M. Zorn
  • TDP-43 mislocalization drives neurofilament changes in a novel model of TDP-43 proteinopathy
    Rachel Atkinson, Jacqueline Leung, James Bender, Matthew Kirkcaldie, James Vickers, Anna King
  • Neural crest-specific loss of Bmp7 leads to...
    Pranidhi Baddam, Vivian Biancardi, Daniela M. Roth, Farah Eaton, Claudine Thereza-Bussolaro, Rupasri Mandal, David S. Wishart, Amy Barr, Joanna MacLean, Carlos Flores-Mir, Silvia Pagliardini, Daniel Graf
  • RET inhibition in novel patient-derived models of RET fusion- positive lung adenocarcinoma reveals...
    Takuo Hayashi, Igor Odintsov, Roger S. Smith, Kota Ishizawa, Allan J. W. Liu, Lukas Delasos, Christopher Kurzatkowski, Huichun Tai, Eric Gladstone, Morana Vojnic, Shinji Kohsaka, Ken Suzawa, Zebing Liu, Siddharth Kunte, Marissa S. Mattar, Inna Khodos, Monika A. Davare, Alexander Drilon, Emily Cheng, Elisa de Stanchina, Marc Ladanyi, Romel Somwar
  • Hearing impairment due to Mir183/96/182...
    Morag A. Lewis, Francesca Di Domenico, Neil J. Ingham, Haydn M. Prosser, Karen P. Steel
  • Inducible expression of human C9ORF72 36× G...
    Fréderike W. Riemslagh, Esmay C. van der Toorn, Rob F. M. Verhagen, Alex Maas, Laurens W. J. Bosman, Renate K. Hukema, Rob Willemsen
  • A muscle growth promoting treatment based on the attenuation of activin/myostatin signalling in...
    Danielle Vaughan, Robert Mitchell, Oliver Kretz, David Chambers, Maciej Lalowski, Helge Amthor, Olli Ritvos, Arja Pasternack, Antonios Matsakas, Sakthivel Vaiyapuri, Tobias B. Huber, Bernd Denecke, Abir Mukherjee, Darius Widera, Ketan Patel
  • Genetic background modifies vulnerability to glaucoma-...
    Nicholas G. Tolman, Revathi Balasubramanian, Danilo G. Macalinao, Alison L. Kearney, Katharine H. MacNicoll, Christa L. Montgomery, Wilhelmine N. de Vries, Ian J. Jackson, Sally H. Cross, Krishnakumar Kizhatil, K. Saidas Nair, Simon W. M. John
  • Cardiovascular phenotype of the Dmdmdx...
    Petra Lujza Szabó, Janine Ebner, Xaver Koenig, Ouafa Hamza, Simon Watzinger, Sandra Trojanek, Dietmar Abraham, Hannes Todt, Helmut Kubista, Klaus Schicker, Séverine Remy, Ignacio Anegon, Attila Kiss, Bruno K. Podesser, Karlheinz Hilber
  • Altered cytoskeletal arrangement in induced pluripotent stem cells and motor neurons from patients...
    Alessia Niceforo, Chiara Marioli, Fiorella Colasuonno, Stefania Petrini, Keith Massey, Marco Tartaglia, Enrico Bertini, Sandra Moreno, Claudia Compagnucci
  • The infantile myofibromatosis NOTCH3 L1519P mutation leads to hyperactivated ligand-independent...
    Dan Wu, Sailan Wang, Daniel V. Oliveira, Francesca Del Gaudio, Michael Vanlandewijck, Thibaud Lebouvier, Christer Betsholtz, Jian Zhao, ShaoBo Jin, Urban Lendahl, Helena Karlström

Journals from The Company of Biologists

Development Journal of Cell Science Journal of Experimental Biology Disease Models & Mechanisms Biology Open

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