Disease Models & Mechanisms (DMM) is an online Open Access journal focusing on the use of model systems to better understand, diagnose and treat human disease.
The primary aim of DMM is to promote human health by inspiring collaboration between basic and clinical researchers in translational science. The journal is committed to presenting rigorously peer-reviewed research that has significant translational impact. The interdisciplinary nature of DMM means that a diverse range of diseases, approaches and models fall within its broad scope. DMM is guided by an international team of expert research-active Editors, led by Monica Justice and Ross Cagan, and supported by an outstanding Editorial Advisory Board.
Our Special Issue - A Guide to Using Neuromuscular Disease Models for Basic and Preclinical Studies - is now open. Click here to read the latest papers.
Editor's choice
Ethan Perlstein and colleagues present two back-to-back articles on drug repurposing screening for rare disease. The first describes how the diabetic neuropathy drug palrestat can ameliorate PMM2-CDG, a congenital disorder of glycosylation.
The second identifies the FDA-approved aripiprazole as a clinical candidate for treating NGLY1 deficiency, an ultra-rare monogenic disorder of glycosylation.
Recent highlights
News from DMM
DMM is proud to be part of an important new initiative launched by EMBO Press and ASAPbio. Review Commons – a platform that peer reviews research manuscripts in the life sciences before submission to a journal – will be launched in December 2019 at the ASCB meeting. Find out more here.
Planning your 2020 diary? Make sure you note our grant and Travelling Fellowship deadlines. The Company of Biologists has a fabulous line up of Workshops scheduled for 2020, with funded places available for early-career researchers. DMM will be attending Inflammaging and Regeneration: Pain or Partnership?, organised by Helen Blau and Nadia Rosenthal (one of DMM’s Founding Editors).
Highlighted articles
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Daniel N. Itzhak, Francesca Sacco, Nagarjuna Nagaraj, Stefka Tyanova, Matthias Mann, Marta Murgia
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Sangeetha Iyer, Joshua D. Mast, Hillary Tsang, Tamy P. Rodriguez, Nina DiPrimio, Madeleine Prangley, Feba S. Sam, Zachary Parton, Ethan O. Perlstein
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Sangeetha Iyer, Feba S. Sam, Nina DiPrimio, Graeme Preston, Jan Verheijen, Kausalya Murthy, Zachary Parton, Hillary Tsang, Jessica Lao, Eva Morava, Ethan O. Perlstein
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Meijiang Liao, Uday Kundap, Richard E. Rosch, Dominic R. W. Burrows, Martin P. Meyer, Bouchra Ouled Amar Bencheikh, Patrick Cossette, Éric Samarut
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Devi Santhosh, Joe Sherman, Shafi Chowdhury, Zhen Huang
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Kuniko Nakajima, Michio Ono, Uroš Radović, Selma Dizdarević, Shin-ichi Tomizawa, Kazushige Kuroha, Go Nagamatsu, Ikue Hoshi, Risa Matsunaga, Takayuki Shirakawa, Takeyuki Kurosawa, Yasunari Miyazaki, Masahide Seki, Yutaka Suzuki, Haruhiko Koseki, Masataka Nakamura, Toshio Suda, Kazuyuki Ohbo
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Ana Rolo, Gabriel L. Galea, Dawn Savery, Nicholas D. E. Greene, Andrew J. Copp
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Yuta Higashikuse, Nishant Mittal, Takuro Arimura, Sung Han Yoon, Mayumi Oda, Hirokazu Enomoto, Ruri Kaneda, Fumiyuki Hattori, Takeshi Suzuki, Atsushi Kawakami, Alexander Gasch, Tetsushi Furukawa, Siegfried Labeit, Keiichi Fukuda, Akinori Kimura, Shinji Makino
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A. Scott Emmert, Eri Iwasawa, Crystal Shula, Preston Schultz, Diana Lindquist, R. Scott Dunn, Elizabeth M. Fugate, Yueh-Chiang Hu, Francesco T. Mangano, June Goto
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Desislava Doycheva, Ningbo Xu, Harpreet Kaur, Jay Malaguit, Devin William McBride, Jiping Tang, John H. Zhang
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Urmas Roostalu, Casper B. G. Salinas, Ditte D. Thorbek, Jacob L. Skytte, Katrine Fabricius, Pernille Barkholt, Linu M. John, Vanessa Isabell Jurtz, Lotte Bjerre Knudsen, Jacob Jelsing, Niels Vrang, Henrik H. Hansen, Jacob Hecksher-Sørensen
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Sonia Sudiwala, Alexandra Palmer, Valentina Massa, Alan J. Burns, Louisa P. E. Dunlevy, Sandra C. P. de Castro, Dawn Savery, Kit-Yi Leung, Andrew J. Copp, Nicholas D. E. Greene