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Disease Models & Mechanisms (DMM) is an Open Access biomedical research journal focusing on the use of model systems to better understand, diagnose and treat human disease.
The primary aim of DMM is to promote human health by inspiring collaboration between basic and clinical researchers in translational science. The journal is committed to presenting rigorously peer-reviewed research that has significant translational impact. The interdisciplinary nature of DMM means that a diverse range of diseases, approaches and models fall within its broad scope. DMM is guided by an international team of expert research-active Editors, led by Monica Justice and Ross Cagan, and supported by an outstanding Editorial Advisory Board.
Editor's choice
In September's Editor's choice, Parvez et al. administered pramipexole (PPX) to rats after a traumatic brain injury (TBI). Evaluated parameters indicate that the neuroprotective effects of PPX are mediated by activation of the Nrf2/HO-1 signaling pathway following TBI.
Also, Tom Look and colleagues present a model of suz12 LOF-induced leukemia, soft tissue sarcoma and pancreatic adenocarcinoma, which will aid in preclinical studies of these diseases.
New reviews from DMM
The APOE ε4 allele and female sex are among the strongest risk factors for late-onset Alzheimer's disease. Chiba-Falek and colleagues explore how the interplay of these factors affects risk for this and other age-related neurodegenerative diseases.
In a new review, Rämet and colleagues discuss how zebrafish and other fish models can complement the more traditional mammalian models in the development of novel vaccines against tuberculosis.
Call for Papers – The RAS Pathway
Highlighted articles
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Stanley M. Walls, Dale A. Chatfield, Karen Ocorr, Greg L. Harris, Rolf Bodmer
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Olga Medina-Martinez, Meade Haller, Jill A. Rosenfeld, Marisol A. O'Neill, Dolores J. Lamb, Milan Jamrich
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Mohd. Salman, Heena Tabassum, Suhel Parvez
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Felix Oppel, Dong H. Ki, Mark W. Zimmerman, Kenneth N. Ross, Ting Tao, Hui Shi, Shuning He, Jon C. Aster, A. Thomas Look
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Rong Li, Baoling Ying, Yanan Liu, Jacqueline F. Spencer, Jinxin Miao, Ann E. Tollefson, James D. Brien, Yaohe Wang, William S. M. Wold, Zhongde Wang, Karoly Toth
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Pratibha Singh, Lady Leidy Sanchez-Fernandez, David Ramiro-Cortijo, Pedro Ochoa-Allemant, George Perides, Yan Liu, Esli Medina-Morales, William Yakah, Steven D. Freedman, Camilia R. Martin
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Josh Echols, Amna Siddiqui, Yanying Dai, Viktoria Havasi, Richard Sun, Aneta Kaczmarczyk, Kim M. Keeling
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Hui-Ying Tsai, Shih-Cheng Wu, Jian-Chiuan Li, Yu-Min Chen, Chih-Chiang Chan, Chun-Hong Chen