- ptf1a+, ela3l− cells are developmentally maintained progenitors for exocrine regeneration following extreme loss of acinar cells in zebrafish larvae
Summary: New transgenic models for exocrine pancreas regeneration in zebrafish reveal a novel potential exocrine progenitor as the source for a two-phase regeneration process after complete acinar cell loss.
- Standardized echocardiographic assessment of cardiac function in normal adult zebrafish and heart disease models
Summary: Standardization of zebrafish echocardiography provides insights into cardiac physiology in normal and diseased states, with application for functional studies in zebrafish models of heart disease.
- Rat models of spinal cord injury: from pathology to potential therapies
Summary: In this Review, we discuss the advantages and disadvantages of the rat for studies of experimental spinal cord injury and summarize the knowledge gained from such studies.
- Gastrointestinal stem cells in health and disease: from flies to humans
Drosophila Collection: This Review highlights recent findings on intestinal stem cell (ISC) diversity in the GI tract of Drosophila, focusing on the role of ISCs in healthy and diseased conditions, and drawing parallels to vertebrate GI stem cells.
- Drosophila tools and assays for the study of human diseases
Editors' choice - Drosophila Collection: In this review and accompanying poster, we highlight the physiological and molecular parallels between fly and human organs that validate the use of Drosophila to study the molecular pathogenesis underlying human diseases.
- A modified choline-deficient, ethionine-supplemented diet reduces morbidity and retains a liver progenitor cell response in mice
Summary: This modified choline-deficient, ethionine-supplemented model induces liver injury in mice and reproducibly minimizes morbidity and mortality, whilst maintaining a liver-progenitor-cell response sufficient for cell-line establishment.
- High-resolution live imaging reveals axon-glia interactions during peripheral nerve injury and repair in zebrafish
Summary: Schwann cells are important components of the peripheral glia. We use microsurgery and high-resolution live imaging to show how Schwann cells control the regeneration of a sensorineural circuit.