- Genetic, physiological and comparative genomic studies of hypertension and insulin resistance in the spontaneously hypertensive rat
Summary: Comparative genome analyses identify candidate genes for hypertension and insulin resistance on rat chromosomes 12 and 16, and marked enrichment of insulin resistance genes in the syntenic regions of the human genome.
- Renal disease pathophysiology and treatment: contributions from the rat
Summary: This Review highlights the key role that the rat continues to play in improving our understanding of the etiologies of renal pathologies, and how these insights have opened up new therapeutic avenues.
- A rat model for hepatitis E virus
Summary: Rat hepatitis E virus strain LA-B350 is used as a model for antiviral studies for hepatitis E virus using a cDNA clone, replicon and in vivo studies.
- Fischer-344 Tp53-knockout rats exhibit a high rate of bone and brain neoplasia with frequent metastasis
Editors' choice: Transferring a Tp53-knockout allele from an outbred rat stock to the F344 inbred rat genetic background alters the spectrum of tumors, providing a model of early-onset brain and bone sarcomas.
- Rodent models in neuroscience research: is it a rat race?
Summary: In this At a Glance poster review, Ellenbroek and Youn describe important differences between rats and mice that impact on their use as model organisms for brain disorders.
- From integrative genomics to systems genetics in the rat to link genotypes to phenotypes
Summary: This Review describes the most recent advances in the field of systems genetics, focusing on the rat. We cover from the first integrative genomics strategies (such as mapping of expression QTLs or eQTLs) and conclude with the most sophisticated gene network-based analyses in multiple systems and disease states.
- Rat models of spinal cord injury: from pathology to potential therapies
Summary: In this Review, we discuss the advantages and disadvantages of the rat for studies of experimental spinal cord injury and summarize the knowledge gained from such studies.
- A RATional choice for translational research?
Summary: This Editorial introduces a new Special Collection, ‘Spotlight on Rat: Translational Impact’, providing a summary of the articles published in this launch issue and a flavour of what's to come, as well as highlighting the impact rat models have made and continue to make on understanding human disease.
- New Wistar Kyoto and spontaneously hypertensive rat transgenic models with ubiquitous expression of green fluorescent protein
Summary: We have created two transgenic models expressing ubiquitous GFP in WKY and SHR rat lines to support in vivo and ex vivo studies. We show their characterisation and discuss their potential use for translational research.