- Genetic, physiological and comparative genomic studies of hypertension and insulin resistance in the spontaneously hypertensive rat
Summary: Comparative genome analyses identify candidate genes for hypertension and insulin resistance on rat chromosomes 12 and 16, and marked enrichment of insulin resistance genes in the syntenic regions of the human genome.
- Using Drosophila to discover mechanisms underlying type 2 diabetes
Drosophila Collection: Studies in Drosophila hold the potential to transform our understanding of the genetics of diabetes. We review important findings and provide a framework for diabetes gene discovery in the fly.
- A mitochondrial therapeutic reverses visual decline in mouse models of diabetes
Summary: Visual decline in mouse models of diabetes is reversed, independently of treating other disease symptoms, by treatment with MTP-131, a water-soluble peptide that selectively targets cardiolipin and improves mitochondrial bioenergetics.
- The lysyl oxidase inhibitor β-aminopropionitrile reduces body weight gain and improves the metabolic profile in diet-induced obesity in rats
Highlighted Article: Lysyl oxidase (LOX) could play a role in the metabolic dysfunction induced by obesity, and consequently the inhibition of LOX activity could be a valuable strategy to ameliorate obesity-related metabolic disturbances.