- Autophagy resolves early retinal inflammation in Igf1-deficient mice
Summary: Igf1-deficient mice show chronic inflammation in the retina, and we reveal that controlling inflammation through autophagy in young mice could prevent loss of retinal function.
- Stem-cell-specific endocytic degradation defects lead to intestinal dysplasia in Drosophila
Drosophila Collection: Intestinal-stem-cell-specific loss of the Drosophila ortholog of the tumor suppressor UVRAG, which is implicated in colorectal cancer, leads to endocytic defects and dysplasia.
- Ethambutol induces impaired autophagic flux and apoptosis in the rat retina
Summary: This study provides the first evidence that EMB induces autophagosome accumulation, which results from the impaired autophagic flux that is mediated by a PKCδ-dependent pathway, and leads to apoptotic death in retina neuronal cells.
- Increased autophagy and apoptosis contribute to muscle atrophy in a myotonic dystrophy type 1 Drosophila model
Summary: Increased apoptosis and autophagy are processes that lead to muscle mass wasting in DM1, which is one of the most debilitating symptoms of the disease.