Herpes simplex virus (HSV) type 1 affects a majority of the population and recent evidence suggests involvement in Alzheimer's disease aetiology.
We investigated HSV (1 and 2) prevalence in the Tampere Autopsy Study (TASTY) brain samples using PCR and sero-positivity in plasma, and associations with Alzheimer's disease neuropathology.
HSV was shown to be present in human brain tissue in 11/584 (1.9%) of samples in the TASTY cohort, and 6 of those samples had Alzheimer's disease neuropathological amyloid beta (Aβ) aggregations. Additionally, serological data revealed 86% were IgG positive for HSV.
In conclusion we report epidemiological evidence of HSV presence in brain tissue without showing encephalitis symptoms in a cohort most closely representing the general population (a minimum prevalence 1.9%). Six out of 11 with HSV DNA in brain tissue had Aβ aggregations, although most of those with Aβ aggregations did not have HSV present in brain tissue.
- Received June 21, 2016.
- Accepted September 20, 2016.
- © 2016. Published by The Company of Biologists Ltd
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