About the Cover
Cover image
Cover: Presence of hydrogen peroxide (H2O2; orange) in the gut of Drosophila melanogaster following infection. Bandarra et al. identified a novel function of the mammalian hypoxia-inducible factor (HIF) and the Drosophila homologue (Sima) in restraining the major inflammation-responsive transcription factor, nuclear factor κB (NF-κB). H2O2 levels were increased in sima loss-of-function transgenic flies following Serratia marcescens infection. HIF-1α was identified as an inhibitor of NF-κB activity, and could therefore be important in preventing excessive and harmful pro-inflammatory responses. See article by Bandarra et al. on page 169.
This issue
Other journals from The Company of Biologists
Review – Collagen VI in healthy and diseased nervous system
Previously, collagen VI has been assocaiated with skeletal muscle homeostasis. Now, Matilde Cescon and colleagues Review a number of recent studies highlighting its key role in the peripheral and central nervous systems, suggesting a link with human neurological disorders.
Featured article – Lifespan analysis of phenotypes in three mouse models of Down syndrome
A comparison of three mouse models of Down syndrome by Diana W. Bianchi and co-workers reveals widespread and unexpected fundamental differences in behavioural, gene expression and brain development phenotypes.
Find out more about the story behind this paper in an interview with first author Nadine M. Aziz.
Editor's choice – SIL1 plays a crucial role in maintaining skeletal muscle proteostasis and physiology
Linda M. Hendershot and colleagues provide molecular insights into the progressive myopathy and cellular compensatory responses attempted upon loss of SIL1, a component of the endoplasmic-reticulum-resident Hsp70 protein-folding machinery.
First Person interviews
Have you seen our interviews with the early-career first authors of our papers? Recently, we caught up with first authors Cameron Johnstone and Nobuhiko Tachibana.
Why should you publish your next paper in DMM?
DMM aims to promote human health by encouraging collaboration between basic and clinical researchers, covering a diverse range of diseases, approaches and models. Our Editors are all active researchers in the field – your peers, colleagues and mentors, who know how much work has gone into every paper. Recently, we have introduced format-free submission, and we accept peer review reports from other journals, making submission as easy as possible for our authors. Send us your next great paper – publish with us and you'll be in good company.
preLights – Mouse vs human synaptic connectivity profiles
Mahesh Karnani highlights a preprint from Tim Jarsky’s team at the Allen Institute for Brain Science that compares synaptic connectivity profiles within cortical layers in neurosurgical samples of human and mouse brain, helping to place findings from the mouse in a translational perspective. The author team also share how they hope the paper and their data will help build neural network computational models.