About the Cover
Cover image
Cover: Presence of hydrogen peroxide (H2O2; orange) in the gut of Drosophila melanogaster following infection. Bandarra et al. identified a novel function of the mammalian hypoxia-inducible factor (HIF) and the Drosophila homologue (Sima) in restraining the major inflammation-responsive transcription factor, nuclear factor κB (NF-κB). H2O2 levels were increased in sima loss-of-function transgenic flies following Serratia marcescens infection. HIF-1α was identified as an inhibitor of NF-κB activity, and could therefore be important in preventing excessive and harmful pro-inflammatory responses. See article by Bandarra et al. on page 169.
This issue
Other journals from The Company of Biologists
Editorial – Human tissue models in cancer research: looking beyond the mouse
Samuel Jackson and Gareth Thomas discuss the limitations of patient-derived xenograft mouse models and highlight initiatives to maximise the use of human tissue in cancer research, with the goal of improving translation and reducing animal experimentation.
DMM Conference Travel Grants
Is there a conference or meeting you'd love to attend but your budget doesn't stretch that far? Apply for a DMM Conference Travel Grant - our next deadline is 31 August. Find out more here.
First person – a new series of interviews
We are pleased to announce a new series of interviews with the first authors of articles published in DMM, giving authors the opportunity to promote themselves alongside their papers and share their thoughts on being an early career researcher. We launch the series with two interviews; the first is with Josefin Fernius, first author on a Research article investigating the subcellular effects of human neurodegenerative disease proteins using Drosophila leg neurons. The second is with Aaro Salminen and Lillian Garrett, co-first authors on a Research article revealing how Meis1 affects motor phenotypes and the sensorimotor system in mice.
Call for papers: Cancer metabolism special collection
DMM invites you to submit original research for a special collection focused on the dysregulation of metabolic pathways in cancer initiation, progression and resistance to treatment. This ongoing collection will be launched with a special issue scheduled for publication in spring 2018, with the special issue guest edited by Almut Schulze (University of Würzberg, Germany) and Mariia Yuneva (Crick Institute, London, UK).
Find out more here.
Travelling Fellowship - Coming in from the cold
Multidisciplinary researcher Blanca Figuerola used a Travelling Fellowship from DMM to visit Dr Angelo Fontan’s lab at the ICB in Italy. There, she learned a number of chemical techniques to help her study the chemical ecology of Antarctic bryozoans on a research campaign to Antarctica. Read her story here.
Where could your research take you? The deadline for the current round of applications for a DMM Travelling Fellowship is 31 August. Find out more here.