About the Cover
Cover image
Cover: Presence of hydrogen peroxide (H2O2; orange) in the gut of Drosophila melanogaster following infection. Bandarra et al. identified a novel function of the mammalian hypoxia-inducible factor (HIF) and the Drosophila homologue (Sima) in restraining the major inflammation-responsive transcription factor, nuclear factor κB (NF-κB). H2O2 levels were increased in sima loss-of-function transgenic flies following Serratia marcescens infection. HIF-1α was identified as an inhibitor of NF-κB activity, and could therefore be important in preventing excessive and harmful pro-inflammatory responses. See article by Bandarra et al. on page 169.
This issue
Other journals from The Company of Biologists
Editor’s choice – Identification of cardioprotective drugs in a Drosophila model of Friedreich's ataxia
Véronique Monnier and colleagues describe a drug screening approach in a Drosophila model of Friedreich's ataxia. This study demonstrates that cardiac functional imaging in adult flies is feasible for in vivo pharmacological screening of candidate cardioprotective compounds.
Review – Probiotics against airway allergy: host factors to consider
In a new Review, Sarah Lebeer and colleagues discuss the host factors that influence the outcomes of in vivo probiotic interventions in allergy, focusing on genetics, sex, age and microbiological status in mouse models of allergic disease.
Special issue - Cancer metabolism
Recent years have brought about a resurgent interest in cancer metabolism. To showcase the recent advances in the field, DMM are currently compiling a special issue, Cancer metabolism: models, mechanisms and targets, guest edited by Almut Schulze and Mariia Yuneva. As the special issue continues to grow, we will showcase the key highlights here.
Model for life – Finding clues in the p53 maze
To open the issue, we spoke to Prof. Karen Vousden about how she came to focus on the many functions of tumour suppressor protein p53 in cancer and beyond.
Review – The metabolic axis of macrophage and immune cell polarization
A new Review by Spencer Hobson-Gutierrez and Carlos Carmona-Fontaine summarises how metabolic cues in the tumour microenvironment affect the immune system, with a special focus on tumour-associated macrophages.
First Person interviews
Have you seen our interviews with the early-career first authors of our papers? Recently, we caught up with first authors Soo-Hyun Kim, Diana Papazova, Genki Hayashi, Ricardo Mondragon-Gonzalez, Derek Erstad and Nelly El-Sakkary
Why should you publish your next paper in DMM?
DMM aims to promote human health by encouraging collaboration between basic and clinical researchers, covering a diverse range of diseases, approaches and models. Our Editors are all active researchers in the field – your peers, colleagues and mentors, who know how much work has gone into every paper. Recently, we have introduced format-free submission, and we accept peer review reports from other journals, making submission as easy as possible for our authors. Send us your next great paper – publish with us and you'll be in good company.
preLights – From GWAS to function
Daniel Grimes highlights a recent preprint from Alexander F. Schier and colleagues, describing a phenotypic atlas of 132 zebrafish mutants to shed light on the role of human schizophrenia-associated genes.
We are pleased to announce that DMM now features recent preLights of interest to the translational biology community as part of each issue's Table of Contents.