Editor's Choice – Lifespan analysis of phenotypes in three mouse models of Down syndrome

A comparison of three mouse models of Down syndrome by Diana W. Bianchi and co-workers reveals widespread and unexpected fundamental differences in behavioural, gene expression and brain development phenotypes.

Find out more about the story behind this Editor's Choice article in an interview with first author Nadine M. Aziz.

Review – Hidden features: exploring the non-canonical functions of metabolic enzymes

A new Review from Peiwei Huangyang and M. Celeste Simon, part of our upcoming special issue on Cancer metabolism, summarizes recent findings about multifaceted metabolic enzymes with non-canonical activities outside their core biochemical functions, and how they may provide new therapeutic strategies for cancers.

Featured article – Intramyocardial angiogenetic stem cells and epicardial erythropoietin save the acute ischemic heart

Gustav Steinhoff and colleagues report that cardiac mesenchymal stem cells respond early to myocardial infarction, and that their regenerative capacity is directly upregulated by optimized stimulation of the heart through epicardial erythropoietin delivery.

First Person interviews 

Have you seen our interviews with the early-career first authors of our papers? Recently, we caught up with first authors Nadine Aziz, Tingting Sui, Brian Lu, Hannah Gordon, Theresa Kisko, Francisco Javier García-Rodríguez and Laura Schultz.

Why should you publish your next paper in DMM?

DMM aims to promote human health by encouraging collaboration between basic and clinical researchers, covering a diverse range of diseases, approaches and models. Our Editors are all active researchers in the field – your peers, colleagues and mentors, who know how much work has gone into every paper. Recently, we have introduced format-free submission, and we accept peer review reports from other journals, making submission as easy as possible for our authors. Send us your next great paper – publish with us and you'll be in good company.

preLights – Using zebrafish to model the effects of candidate disease gene variants in complex human genetic disorders

Highlighted by Hannah Brunsdon, a recent preprint from Lisa Maves and co-workers describes the first example of modelling a complex genetic disorder in zebrafish, and demonstrates that a human candidate disease variant of unknown significance acts as a modifier gene for congenital heart defects.