Vivo-Morpholinos: Same oligos, from cultures to critters -


Obesity and psychotic disorders: uncovering common mechanisms through metabolomics
Matej Orešič


Primary obesity and psychotic disorders are similar with respect to the associated changes in energy balance and co-morbidities, including metabolic syndrome. Such similarities do not necessarily demonstrate causal links, but instead suggest that specific causes of and metabolic disturbances associated with obesity play a pathogenic role in the development of co-morbid disorders, potentially even before obesity develops. Metabolomics – the systematic study of metabolites, which are small molecules generated by the process of metabolism – has been important in elucidating the pathways underlying obesity-associated co-morbidities. This review covers how recent metabolomic studies have advanced biomarker discovery and the elucidation of mechanisms underlying obesity and its co-morbidities, with a specific focus on metabolic syndrome and psychotic disorders. The importance of identifying metabolic markers of disease-associated intermediate phenotypes – traits modulated but not encoded by the DNA sequence – is emphasized. Such markers would be applicable as diagnostic tools in a personalized healthcare setting and might also open up novel therapeutic avenues.


  • This article is part of a special issue on obesity: see related articles in Vol. 5, issue 5 of Dis. Model. Mech. at


    The author declares that they do not have any financial or competing interests.


    This work was supported by the Academy of Finland Centre of Excellence in Molecular Systems Immunology and Physiology Research (SyMMyS, 2012–2017, Decision No. 250114) and by the project ‘Characterization and modelling of dietary effects mediated by gut microbiota on lipid metabolism’, which was supported by the European Commission under the 7th Framework Programme (contract FP7-KBBE-222639).

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