Traumatic brain injury (TBI) is the most common type of brain injury. Therapies that stimulate endogenous neural stem cells might enable regeneration of damaged neural tissue, but the mechanisms by which these cells can be activated are not clear. Kishimoto et al. use a zebrafish model of TBI and in vivo imaging to show that neural precursor cells in the adult tencephalon proliferate following brain injury, migrate towards the lesion site and differentiate into mature neurons in a Notch1-pathway-dependent manner. This model can be used to further elucidate pathways that could be targeted to induce neural repair in humans affected by TBI. Page 200
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