Re-gain of weight lost during dieting – known as post-restriction hyperphagia (PRH) – is commonly observed but not well understood. Hambly et al. study this phenomenon in mice and find that a decrease in fat mass, and the signals produced by fat mass, are partly to blame. Mice on a restricted diet have decreased circulating levels of leptin and tumour necrosis factor-α (TNFα), and supplementation of these factors to non-restriction levels suppresses PRH. These data might help to develop targeted therapies that improve the outcome of dieting in obese individuals. Page 83
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