Usher syndrome is a recessively inherited disease of combined deafness and blindness that can be caused by a mutation in several genes. Phillips et al. investigate the genotype-phenotype link for one of these genes, USHC1, by studying the effects of ush1c deficiency in zebrafish. ush1c mutant or morphant fish have early-onset defects in vision, hearing and balance, associated with defects in sensory cell structure and, in particular, in Müller glia, suggesting that this retinal cell type might be involved in the pathology of Usher syndrome in humans. Page 786
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