Oxidative stress is thought to be central to the pathogenesis of Parkinson’s disease (PD). Nrf2, which regulates cellular antioxidant responses, has previously been implicated as neuroprotective in PD. Barone et al. now show that upregulation of the Nrf2 pathway, or inhibition of its negative regulator, Keap1, is sufficient to restore defective locomotor activity in a fly model of PD. Moreover, the loss of dopaminergic neurons (a hallmark of PD pathology) is inhibited when the Nrf2 pathway is upregulated. Therefore, the neuroprotective potential of Nrf2 pathway components in PD warrants further study. Page 701
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