Drugs that maintain homeostatic Ca2+ levels might be a promising therapy for Alzheimer’s disease (AD), but systems to test them efficiently are lacking. Copenhaver et al. now report a ‘translational suite’ comprising four bioassays relevant to AD pathology –including in vitro screening, Drosophila, Manduca and the 3×Tg mouse model of AD – to test the therapeutic potential of dihydropyridines (DHPs), which target low-voltage-gated Ca2+ channels. One compound, isradipine, provides neuroprotection and minimal toxicity in all four assays, supporting this compound as a candidate drug for AD and validating this multi-pronged approach for drug development. Page 634
- Written by editorial staff. © 2011. Published by The Company of Biologists Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.