Congenital heart disease is a common inherited birth defect. Much is known about electrical conduction and Ca2+ handling in the adult heart, but not about how these characteristics are established during embryogenesis. Wythe et al. use a zebrafish embryo screen to identify a highly conserved gene encoding heart adaptor protein 1 (HADP1), a membrane-bound factor that interacts with phosphatidylinositol (PI) derivatives. Pharmacological experiments implicate PI4-kinase (PI4K) as an upstream regulator of HADP1 function, indicating that interaction between PI4K and Ca2+ signalling might regulate heart morphogenesis, function and disease. Page 607
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