Special issue - Cancer metabolism

Recent years have brought about a resurgent interest in cancer metabolism. To showcase the recent advances in the field, DMM presents Cancer metabolism: models, mechanisms and targets, a special issue guest edited by Almut Schulze (University of Würzberg, Germany) and Mariia Yuneva (The Francis Crick Institute, UK). Our guest editors introduce the special issue in an Editorial, and discuss recent advances in the field of cancer metabolism, as well as the challenges faced as this exciting research progresses.

Issue highlights include:

At a glance – Immunometabolism in cancer at a glance

In this review and accompanying poster, Peter J. Siska and colleagues address how tumors can negatively affect immune cells through depletion of critical nutrients or through production of toxic metabolic products.

Review – Arginine and the metabolic regulation of nitric oxide synthesis in cancer

Rom Keshet and Ayelet Erez review the regulation of NO levels by the synthesis and availability of arginine, and on the implications of this metabolic regulation to cancer biology and therapy.

Journal meeting – Blood disorders: models, mechanisms and therapies

Register your interest in our upcoming meeting on blood disorders and their treatment, organised by DMM Editor-in-Chief Monica Justice, Nancy Speck, Paresh Vyas and Leonard Zon. The meeting will bring together diverse front-line researchers, stimulating discussions across basic research and clinical disciplines, and fostering collaborative links among researchers.

Why should you publish your next paper in DMM?

DMM aims to promote human health by encouraging collaboration between basic and clinical researchers, covering a diverse range of diseases, approaches and models. Our Editors are all active researchers in the field – your peers, colleagues and mentors, who know how much work has gone into every paper. Recently, we have introduced format-free submission, and we accept peer review reports from other journals, making submission as easy as possible for our authors. Send us your next great paper – publish with us and you'll be in good company.

preLights – When not recycling cleans a mess; halting tumor-associated vascular overgrowth by blocking lipid recycling

Coert Margadant highlights a recent preprint from Brant M Weinstein and colleagues that shows how a ‘classic’ pro-angiogenic signal such as VEGF can be turned into an anti-angiogenic signal by changing the balance between consumption and recycling of essential downstream mediators.