About the Cover
Cover image

Cover: Mouse mammary tumor (MMT) invading the mammary fat pad. Both single-cell and collective invasion originate from 3D tumoroids 4 days after microimplantation. Carcinoma cells are visualized by H2B-eGFP in the nuclei (green) and DsRed2 in the cytoplasm (red). Blood vessels are visualized by fluorescent 70 kDa dextran (cyan). See article by Ilina et al. (dmm034330). Cover image is licensed under a Creative Commons Attribution 4.0 International license.
This issue

- Open Access
Reverse genetic screen reveals that Il34 facilitates yolk sac macrophage distribution and seeding of the brain
Laura E. Kuil, Nynke Oosterhof, Samuël N. Geurts, Herma C. van der Linde, Erik Meijering, Tjakko J. van Ham - Open Access
Differential regulation of the unfolded protein response in outbred deer mice and susceptibility to metabolic disease
A. Havighorst, Y. Zhang, E. Farmaki, V. Kaza, I. Chatzistamou, H. Kiaris - Open Access
Leptin induces muscle wasting in kras-driven hepatocellular carcinoma (HCC) model in zebrafish
Qiqi Yang, Chuan Yan, Xu Wang, Zhiyuan Gong - Open Access
Serotonin inhibits axonal regeneration of identifiable descending neurons after a complete spinal cord injury in lampreys
Daniel Sobrido-Cameán, Diego Robledo, Laura Sánchez, María Celina Rodicio, Antón Barreiro-Iglesias - Open Access
VPS13A, a closely associated mitochondrial protein, is required for efficient lysosomal degradation
Sandra Muñoz-Braceras, Alba R. Tornero-Écija, Olivier Vincent, Ricardo Escalante
Other journals from The Company of Biologists
Editor’s choice – The ubiquitin ligase HECTD1 promotes retinoic acid signaling required for development of the aortic arch
This month’s Editor’s choice is from Irene Zohn's group. They identify the ubiquitin ligase HECTD1 as a novel modulator of retinoic acid signalling, providing a model for the complex interactions in aortic arch development.
At a Glance - Generating mouse models for biomedical research: technological advances
Newer molecular technologies to precisely and efficiently manipulate the mammalian genome are enabling the production of more scientifically valuable animal models, show Channabasavaiah Gurumurthy and Kent Lloyd in this poster.
In this Review Abraham Acevedo-Arozena and team compare two key types of amyotrophic lateral sclerosis (ALS) mouse models: transgenic mice and those that express genes at physiological levels.
Have you seen our interviews with the early-career first authors of our papers? The authors talk about their work in and out of the lab, the journeys that led them to where they are now and the scientists who inspired them along the way. Recently, we caught up with Piotr Soczewka.
Call for papers – A guide to using neuromuscular disease models for basic and preclinical studies
We invite you to submit original research for a Special Collection focused on neuromuscular disease models, edited by Annemieke Aartsma-Rus, James Dowling and Maaike van Putten. The collection will showcase studies on the dysregulation of pathways, disease progression, approaches to treat and modify disease course in animal models, technologies for studying muscle pathophysiology and regeneration, and advances in the development of suitable in vitro and in vivo models. Submission deadline: 3 June 2019.
Why should you publish your next paper in DMM?
DMM aims to promote human health by encouraging collaboration between basic and clinical researchers, covering a diverse range of diseases, approaches and models. Our Editors are all active researchers in the field – your peers, colleagues and mentors, who know how much work has gone into every paper. DMM offers format-free submission and accepts peer review reports from other journals, making submission as easy as possible for our authors. Send us your next great paper – publish with us and you'll be in good company.
preLights - Mechanical stretch kills transformed cancer cells
Joseph Thottacherry highlights a recent preprint from Michael Sheetz and colleagues, who test the importance of forces in selective apoptosis of cancer cells and the mechanisms regulating these. They find cancer cells are extremely sensitive to mechanoptosis.