Table of Contents
- Rethinking cancer: current challenges and opportunities in cancer research
Summary: Pablo Meyer and Ross Cagan discuss the main themes emerging from a recent workshop ‘Rethinking Cancer’, highlighting the key challenges faced by the research community and outlining potential strategies to promote translation of basic findings.
A MODEL FOR LIFE
- Waging war against pancreatic cancer: an interview with David Tuveson
Summary: David Tuveson describes some of the key moments and breakthroughs in his remarkable career, and the path that he's followed in his quest for a cure for pancreatic cancer.
- In vivo models in breast cancer research: progress, challenges and future directions
Summary: This Review provides a summary of the many varied uses of mouse models in breast cancer research focusing on their strengths, challenges and future directions.
- Identifying genes for neurobehavioural traits in rodents: progress and pitfalls
Summary: This Review discusses the rodent resources that exist to map neurobehavioural traits at high resolution and identify causal variants and genes.
- MAPK signaling pathways and HDAC3 activity are disrupted during differentiation of emerin-null myogenic progenitor cells
Editors' choice: HDAC3, p38 MAPK and ERK signaling are altered during differentiation of myogenic progenitors lacking emerin; pharmacological activation or inhibition of these signaling proteins rescues specific stages of myogenic differentiation.
- A Drosophila model of myeloproliferative neoplasm reveals a feed-forward loop in the JAK pathway mediated by p38 MAPK signalling
Summary: Pro-tumourigenic crosstalk occurs between the p38 MAPK pathway and JAK signalling in a Drosophila model of myeloproliferative neoplasm.
- Heterozygous Vangl2Looptail mice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair
Summary: Manipulating the PCP pathway may provide new approaches to treat damaged lung tissue.
- Gene expression profiles among murine strains segregate with distinct differences in the progression of radiation-induced lung disease
Summary: Rational mouse model selection is crucial for identifying new therapeutic targets and screening medical interventions in acute pneumonitis and/or late fibrosis following thoracic irradiation.
- Overexpression of mitochondrial oxodicarboxylate carrier (ODC1) preserves oxidative phosphorylation in a yeast model of Barth syndrome
Summary: Transport of oxodicarboxylic acid (ODC1) across the mitochondrial inner membrane is a potential target for the treatment of BTHS patients and other diseases caused by mitochondrial dysfunction.
- Towards trans-diagnostic mechanisms in psychiatry: neurobehavioral profile of rats with a loss-of-function point mutation in the dopamine transporter gene
Summary: The first systematic RDoc study of a disease mechanism proposes dopamine transporter DAT mutant rats as a model for drug development, targeting a hyperdopaminergic state.
- New insights into the regulatory function of CYFIP1 in the context of WAVE- and FMRP-containing complexes
Summary: CYFIP1 and FMRP interact antagonistically during neuromuscular junction growth in the fly and during new neuron differentiation in the olfactory bulb of the adult mouse.
- Genetic dissection of anterior segment dysgenesis caused by a Col4a1 mutation in mouse
Summary: Key pathogenic events in anterior segment dysgenesis, a congenital ocular disease with complex etiology, are recapitulated in a mouse model of Col4a1-related ASD.
- Immortalized human myotonic dystrophy muscle cell lines to assess therapeutic compounds
Summary: Myotonic dystrophy muscle cell models displaying characteristic disease-associated molecular features can be used to investigate molecular pathophysiological mechanisms and evaluate therapeutic approaches.