From single-celled organisms to patient-derived models, cancer to neurodegeneration, DMM publishes the best original research and resources that focus on the use of model systems to better understand, diagnose and treat human disease. Submit your paper here.
What questions you should be asking yourself before you start screening for drugs using model systems? Read the editorial from our Senior Editor Ross Cagan to avoid the common pitfalls of drug discovery and development.
In this month’s highlighted paper, Kurata and colleagues explain how Drosophila larvae represent a useful model of the infectious inflammation and sterilely induced humoral innate responses that underlie disorders associated with chronic inflammation.
Yang et al. present a phenotype-based chemical screen in zebrafish that identifies miconazole as a novel hemorrhagic suppressor. Miconazole inhibits vessel rupture and hemorrhages by decreasing pErk and MMP9 in zebrafish and rats.