Table of Contents
REVIEW
- MicroRNAs in the etiology of colorectal cancer: pathways and clinical implications
Summary: This Review provides an overview of some important microRNAs and their roles in colorectal cancer.
RESEARCH ARTICLES
- Diabetic polyneuropathy, sensory neurons, nuclear structure and spliceosome alterations: a role for CWC22
Summary: Subtle alterations in spliceosome structure and function in diabetic sensory neurons, including dysregulated Cajal bodies and CWC22 overexpression, might promote the development of diabetic sensory polyneuropathy.
- Modeling the ferrochelatase c.315-48C modifier mutation for erythropoietic protoporphyria (EPP) in mice
Summary: A new mouse model reproduces the predominant genetic disposition of patients affected by erythropoietic protoporphyria, a rare disease associated with extreme pain after light exposure.
- Vertical sleeve gastrectomy reduces blood pressure and hypothalamic endoplasmic reticulum stress in mice
Summary: Vertical sleeve gastrectomy in mice decreases blood pressure independent of body mass, which may be due to a decrease in hypothalamic ER stress.
- A novel mouse model of anterior segment dysgenesis (ASD): conditional deletion of Tsc1 disrupts ciliary body and iris development
Summary: Conditional deletion of Tsc1 in the developing eye results in ciliary body and iris hypotrophy, demonstrating that aberrant mTORC1 signalling contributes to anterior segment dysgenesis (ASD).
- Systemic autoimmunity induced by the TLR7/8 agonist Resiquimod causes myocarditis and dilated cardiomyopathy in a new mouse model of autoimmune heart disease
Summary: A novel mouse model of autoimmune-mediated heart damage to study the underlying mechanisms and test therapeutic options for systemic autoimmunity.
- A novel mode of induction of the humoral innate immune response in Drosophila larvae
Editors' choice: Drosophila larvae represent a useful model of infectious inflammation and sterilely induced humoral innate response, which are relevant for disorders associated with chronic inflammation.
- Intestinal epithelial cell caveolin 1 regulates fatty acid and lipoprotein cholesterol plasma levels
Summary: Caveolin 1, which forms caveolae, localizes to the basolateral membrane of zebrafish intestinal epithelial cells and regulates circulating murine fatty acid and lipoprotein cholesterol levels.
- Genetic, physiological and comparative genomic studies of hypertension and insulin resistance in the spontaneously hypertensive rat
Summary: Comparative genome analyses identify candidate genes for hypertension and insulin resistance on rat chromosomes 12 and 16, and marked enrichment of insulin resistance genes in the syntenic regions of the human genome.
- ptf1a+, ela3l− cells are developmentally maintained progenitors for exocrine regeneration following extreme loss of acinar cells in zebrafish larvae
Summary: New transgenic models for exocrine pancreas regeneration in zebrafish reveal a novel potential exocrine progenitor as the source for a two-phase regeneration process after complete acinar cell loss.
- Long-lasting memory deficits in mice withdrawn from cocaine are concomitant with neuroadaptations in hippocampal basal activity, GABAergic interneurons and adult neurogenesis
Summary: Hippocampal functional activity and neuroplasticity are altered in mice long withdrawn from cocaine, with concomitant memory deficits, emphasizing the role of the hippocampus in persistent cognitive manifestation of cocaine withdrawal.
- Miconazole protects blood vessels from MMP9-dependent rupture and hemorrhage
Summary: A phenotype-based chemical screen in zebrafish identifies miconazole as a novel hemorrhagic suppressor. Miconazole inhibits vessel rupture and hemorrhages by decreasing pErk and MMP9 in zebrafish and rats.
This issue
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Other journals from The Company of Biologists
Review – Collagen VI in healthy and diseased nervous system
Previously, collagen VI has been assocaiated with skeletal muscle homeostasis. Now, Matilde Cescon and colleagues Review a number of recent studies highlighting its key role in the peripheral and central nervous systems, suggesting a link with human neurological disorders.
Featured article – Lifespan analysis of phenotypes in three mouse models of Down syndrome
A comparison of three mouse models of Down syndrome by Diana W. Bianchi and co-workers reveals widespread and unexpected fundamental differences in behavioural, gene expression and brain development phenotypes.
Find out more about the story behind this paper in an interview with first author Nadine M. Aziz.
Editor's choice – SIL1 plays a crucial role in maintaining skeletal muscle proteostasis and physiology
Linda M. Hendershot and colleagues provide molecular insights into the progressive myopathy and cellular compensatory responses attempted upon loss of SIL1, a component of the endoplasmic-reticulum-resident Hsp70 protein-folding machinery.
First Person interviews
Have you seen our interviews with the early-career first authors of our papers? Recently, we caught up with first authors Cameron Johnstone and Nobuhiko Tachibana.
Why should you publish your next paper in DMM?
DMM aims to promote human health by encouraging collaboration between basic and clinical researchers, covering a diverse range of diseases, approaches and models. Our Editors are all active researchers in the field – your peers, colleagues and mentors, who know how much work has gone into every paper. Recently, we have introduced format-free submission, and we accept peer review reports from other journals, making submission as easy as possible for our authors. Send us your next great paper – publish with us and you'll be in good company.
preLights – Mouse vs human synaptic connectivity profiles
Mahesh Karnani highlights a preprint from Tim Jarsky’s team at the Allen Institute for Brain Science that compares synaptic connectivity profiles within cortical layers in neurosurgical samples of human and mouse brain, helping to place findings from the mouse in a translational perspective. The author team also share how they hope the paper and their data will help build neural network computational models.