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Table of Contents

March 1, 2017; 10 (3)

REVIEW

  • Open Access
    MicroRNAs in the etiology of colorectal cancer: pathways and clinical implications
    Ashlee M. Strubberg, Blair B. Madison
    Disease Models & Mechanisms 2017 10: 197-214; doi: 10.1242/dmm.027441

    Summary: This Review provides an overview of some important microRNAs and their roles in colorectal cancer.

RESEARCH ARTICLES

  • Open Access
    Diabetic polyneuropathy, sensory neurons, nuclear structure and spliceosome alterations: a role for CWC22
    Masaki Kobayashi, Ambika Chandrasekhar, Chu Cheng, Jose A. Martinez, Hilarie Ng, Cristiane de la Hoz, Douglas W. Zochodne
    Disease Models & Mechanisms 2017 10: 215-224; doi: 10.1242/dmm.028225

    Summary: Subtle alterations in spliceosome structure and function in diabetic sensory neurons, including dysregulated Cajal bodies and CWC22 overexpression, might promote the development of diabetic sensory polyneuropathy.

  • Open Access
    Modeling the ferrochelatase c.315-48C modifier mutation for erythropoietic protoporphyria (EPP) in mice
    Jasmin Barman-Aksözen, Paulina C´wiek, Vijay B. Bansode, Frank Koentgen, Judith Trüb, Pawel Pelczar, Paolo Cinelli, Xiaoye Schneider-Yin, Daniel Schümperli, Elisabeth I. Minder
    Disease Models & Mechanisms 2017 10: 225-233; doi: 10.1242/dmm.027755

    Summary: A new mouse model reproduces the predominant genetic disposition of patients affected by erythropoietic protoporphyria, a rare disease associated with extreme pain after light exposure.

  • Open Access
    Vertical sleeve gastrectomy reduces blood pressure and hypothalamic endoplasmic reticulum stress in mice
    Anne K. McGavigan, Zachariah M. Henseler, Darline Garibay, Scott D. Butler, Sisitha Jayasinghe, Ruth E. Ley, Robin L. Davisson, Bethany P. Cummings
    Disease Models & Mechanisms 2017 10: 235-243; doi: 10.1242/dmm.027474

    Summary: Vertical sleeve gastrectomy in mice decreases blood pressure independent of body mass, which may be due to a decrease in hypothalamic ER stress.

  • Open Access
    A novel mouse model of anterior segment dysgenesis (ASD): conditional deletion of Tsc1 disrupts ciliary body and iris development
    Anna-Carin Hägglund, Iwan Jones, Leif Carlsson
    Disease Models & Mechanisms 2017 10: 245-257; doi: 10.1242/dmm.028605

    Summary: Conditional deletion of Tsc1 in the developing eye results in ciliary body and iris hypotrophy, demonstrating that aberrant mTORC1 signalling contributes to anterior segment dysgenesis (ASD).

  • Open Access
    Systemic autoimmunity induced by the TLR7/8 agonist Resiquimod causes myocarditis and dilated cardiomyopathy in a new mouse model of autoimmune heart disease
    Muneer G. Hasham, Nicoleta Baxan, Daniel J. Stuckey, Jane Branca, Bryant Perkins, Oliver Dent, Ted Duffy, Tolani S. Hameed, Sarah E. Stella, Mohammed Bellahcene, Michael D. Schneider, Sian E. Harding, Nadia Rosenthal, Susanne Sattler
    Disease Models & Mechanisms 2017 10: 259-270; doi: 10.1242/dmm.027409

    Summary: A novel mouse model of autoimmune-mediated heart damage to study the underlying mechanisms and test therapeutic options for systemic autoimmunity.

  • Open Access
    A novel mode of induction of the humoral innate immune response in Drosophila larvae
    Hiroyuki Kenmoku, Aki Hori, Takayuki Kuraishi, Shoichiro Kurata
    Disease Models & Mechanisms 2017 10: 271-281; doi: 10.1242/dmm.027102

    Editors' choice: Drosophila larvae represent a useful model of infectious inflammation and sterilely induced humoral innate response, which are relevant for disorders associated with chronic inflammation.

  • Open Access
    Intestinal epithelial cell caveolin 1 regulates fatty acid and lipoprotein cholesterol plasma levels
    Jessica P. Otis, Meng-Chieh Shen, Vanessa Quinlivan, Jennifer L. Anderson, Steven A. Farber
    Disease Models & Mechanisms 2017 10: 283-295; doi: 10.1242/dmm.027300

    Summary: Caveolin 1, which forms caveolae, localizes to the basolateral membrane of zebrafish intestinal epithelial cells and regulates circulating murine fatty acid and lipoprotein cholesterol levels.

  • Open Access
    Genetic, physiological and comparative genomic studies of hypertension and insulin resistance in the spontaneously hypertensive rat
    Philip M. Coan, Oliver Hummel, Ana Garcia Diaz, Marjorie Barrier, Neza Alfazema, Penny J. Norsworthy, Michal Pravenec, Enrico Petretto, Norbert Hübner, Timothy J. Aitman
    Disease Models & Mechanisms 2017 10: 297-306; doi: 10.1242/dmm.026716

    Summary: Comparative genome analyses identify candidate genes for hypertension and insulin resistance on rat chromosomes 12 and 16, and marked enrichment of insulin resistance genes in the syntenic regions of the human genome.

  • Open Access
    ptf1a+, ela3l− cells are developmentally maintained progenitors for exocrine regeneration following extreme loss of acinar cells in zebrafish larvae
    Nicole Schmitner, Kenji Kohno, Dirk Meyer
    Disease Models & Mechanisms 2017 10: 307-321; doi: 10.1242/dmm.026633

    Summary: New transgenic models for exocrine pancreas regeneration in zebrafish reveal a novel potential exocrine progenitor as the source for a two-phase regeneration process after complete acinar cell loss.

  • Open Access
    Long-lasting memory deficits in mice withdrawn from cocaine are concomitant with neuroadaptations in hippocampal basal activity, GABAergic interneurons and adult neurogenesis
    David Ladrón de Guevara-Miranda, Carmelo Millón, Cristina Rosell-Valle, Mercedes Pérez-Fernández, Michele Missiroli, Antonia Serrano, Francisco J. Pavón, Fernando Rodríguez de Fonseca, Magdalena Martínez-Losa, Manuel Álvarez-Dolado, Luis J. Santín, Estela Castilla-Ortega
    Disease Models & Mechanisms 2017 10: 323-336; doi: 10.1242/dmm.026682

    Summary: Hippocampal functional activity and neuroplasticity are altered in mice long withdrawn from cocaine, with concomitant memory deficits, emphasizing the role of the hippocampus in persistent cognitive manifestation of cocaine withdrawal.

  • Open Access
    Miconazole protects blood vessels from MMP9-dependent rupture and hemorrhage
    Ran Yang, Yunpei Zhang, Dandan Huang, Xiao Luo, Liangren Zhang, Xiaojun Zhu, Xiaolin Zhang, Zhenming Liu, Jing-Yan Han, Jing-Wei Xiong
    Disease Models & Mechanisms 2017 10: 337-348; doi: 10.1242/dmm.027268

    Summary: A phenotype-based chemical screen in zebrafish identifies miconazole as a novel hemorrhagic suppressor. Miconazole inhibits vessel rupture and hemorrhages by decreasing pErk and MMP9 in zebrafish and rats.

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DMM aims to promote human health by encouraging collaboration between basic and clinical researchers, covering a diverse range of diseases, approaches and models. Our Editors are all active researchers in the field – your peers, colleagues and mentors, who know how much work has gone into every paper. Recently, we have introduced format-free submission, and we accept peer review reports from other journals, making submission as easy as possible for our authors. Send us your next great paper – publish with us and you'll be in good company.

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