Table of Contents
REVIEW
- MicroRNAs in the etiology of colorectal cancer: pathways and clinical implications
Summary: This Review provides an overview of some important microRNAs and their roles in colorectal cancer.
RESEARCH ARTICLES
- Diabetic polyneuropathy, sensory neurons, nuclear structure and spliceosome alterations: a role for CWC22
Summary: Subtle alterations in spliceosome structure and function in diabetic sensory neurons, including dysregulated Cajal bodies and CWC22 overexpression, might promote the development of diabetic sensory polyneuropathy.
- Modeling the ferrochelatase c.315-48C modifier mutation for erythropoietic protoporphyria (EPP) in mice
Summary: A new mouse model reproduces the predominant genetic disposition of patients affected by erythropoietic protoporphyria, a rare disease associated with extreme pain after light exposure.
- Vertical sleeve gastrectomy reduces blood pressure and hypothalamic endoplasmic reticulum stress in mice
Summary: Vertical sleeve gastrectomy in mice decreases blood pressure independent of body mass, which may be due to a decrease in hypothalamic ER stress.
- A novel mouse model of anterior segment dysgenesis (ASD): conditional deletion of Tsc1 disrupts ciliary body and iris development
Summary: Conditional deletion of Tsc1 in the developing eye results in ciliary body and iris hypotrophy, demonstrating that aberrant mTORC1 signalling contributes to anterior segment dysgenesis (ASD).
- Systemic autoimmunity induced by the TLR7/8 agonist Resiquimod causes myocarditis and dilated cardiomyopathy in a new mouse model of autoimmune heart disease
Summary: A novel mouse model of autoimmune-mediated heart damage to study the underlying mechanisms and test therapeutic options for systemic autoimmunity.
- A novel mode of induction of the humoral innate immune response in Drosophila larvae
Editors' choice: Drosophila larvae represent a useful model of infectious inflammation and sterilely induced humoral innate response, which are relevant for disorders associated with chronic inflammation.
- Intestinal epithelial cell caveolin 1 regulates fatty acid and lipoprotein cholesterol plasma levels
Summary: Caveolin 1, which forms caveolae, localizes to the basolateral membrane of zebrafish intestinal epithelial cells and regulates circulating murine fatty acid and lipoprotein cholesterol levels.
- Genetic, physiological and comparative genomic studies of hypertension and insulin resistance in the spontaneously hypertensive rat
Summary: Comparative genome analyses identify candidate genes for hypertension and insulin resistance on rat chromosomes 12 and 16, and marked enrichment of insulin resistance genes in the syntenic regions of the human genome.
- ptf1a+, ela3l− cells are developmentally maintained progenitors for exocrine regeneration following extreme loss of acinar cells in zebrafish larvae
Summary: New transgenic models for exocrine pancreas regeneration in zebrafish reveal a novel potential exocrine progenitor as the source for a two-phase regeneration process after complete acinar cell loss.
- Long-lasting memory deficits in mice withdrawn from cocaine are concomitant with neuroadaptations in hippocampal basal activity, GABAergic interneurons and adult neurogenesis
Summary: Hippocampal functional activity and neuroplasticity are altered in mice long withdrawn from cocaine, with concomitant memory deficits, emphasizing the role of the hippocampus in persistent cognitive manifestation of cocaine withdrawal.
- Miconazole protects blood vessels from MMP9-dependent rupture and hemorrhage
Summary: A phenotype-based chemical screen in zebrafish identifies miconazole as a novel hemorrhagic suppressor. Miconazole inhibits vessel rupture and hemorrhages by decreasing pErk and MMP9 in zebrafish and rats.
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Featured article - Generation of a multipurpose Prdm16 mouse allele by targeted gene trapping
This Research article from Bryan C. Bjork and co-workers describes the first targeting of an invertible gene trap to generate a conditional Prdm16 mouse allele and its use to assess phenotypic consequences of Prdm16 loss during craniofacial and brain development.
Review - Cell models of arrhythmogenic cardiomyopathy: advances and opportunities
Elena Sommariva and colleagues reappraise past discoveries in in vitro models of arrhythmogenic cardiomyopathy (ACM) in this Review, providing insights into the molecular mechanisms of this disease.
Editor’s choice - Small-molecule therapeutic boosts spatial memory and motor function in Rett syndrome mice
Rett syndrome is caused by a mutation triggering decreased levels of protein BDNF. Small-molecule BDNF mimetic, LM22A-4, has previously been shown to improve respiratory problems associated with the disease. Now, new research from Lucas Pozzo-Miller and colleagues reveals that LM22A-4 may also improve spatial memory and motor skill defects in a Rett syndrome mouse model. Read the Research article here, and the press release here.
Featured article - Imaging of viral neuroinvasion in the zebrafish reveals that Sindbis and chikungunya viruses favour different entry routes
In this Research article from Gabriella Passoni and co-workers, imaging of neuroinvasion in zebrafish shows that chikungunya virus first infects the blood-brain barrier, whereas Sindbis virus relies on axonal transport.
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