Table of Contents
- Drosophila and genome-wide association studies: a review and resource for the functional dissection of human complex traits
Summary: The use of Drosophila for functional investigation of findings from human genome-wide association studies (GWAS) has potential for follow-up of susceptibility signals in more than 1000 human traits.
- Helicobacter pylori-induced gastric pathology: insights from in vivo and ex vivo models
Summary: Helicobacter pylori-induced gastric pathology remains a common cause of morbidity and mortality. This Review discusses the animal models of these conditions, together with recently described ex vivo culture models.
- A homozygous FITM2 mutation causes a deafness-dystonia syndrome with motor regression and signs of ichthyosis and sensory neuropathy
Editors' choice: Loss of FITM2 function in humans causes syndromic hearing loss without any signs of a lipodystrophy, although FITM2 is known to function in lipid droplet synthesis and metabolism.
- Mosaic expression of Atrx in the mouse central nervous system causes memory deficits
Summary: Heterozygous expression of the X-linked gene Atrx in the mouse brain causes deficits in spatial, contextual fear and object recognition memory.
- Pituitary adenylate cyclase-activating polypeptide (PACAP) has a neuroprotective function in dopamine-based neurodegeneration in rat and snail parkinsonian models
Summary: PACAP has a neuroprotective effect in different toxin-induced rat and snail parkinsonian models, acting partially through the same mechanisms.
- Seizure control through genetic and pharmacological manipulation of Pumilio in Drosophila: a key component of neuronal homeostasis
Summary: Next-generation anticonvulsant compounds potentiate the activity of the neuronal homeostatic regulator Pumilio.
- A model of type 2 diabetes in the guinea pig using sequential diet-induced glucose intolerance and streptozotocin treatment
Summary: The guinea pig can act as a tool for investigators interested in the translational manifestations of diabetes using new methods for induction of type 2 diabetes.
- Broad AOX expression in a genetically tractable mouse model does not disturb normal physiology
Summary: Previous limitations are overcome in this first genetically tractable mouse model expressing invertebrate alternative oxidase, AOX, which can suppress pathological stresses in the mitochondrial respiratory chain.
- A novel swine model of ricin-induced acute respiratory distress syndrome
Summary: Lung injury induced by intratracheal instillation of ricin to swine exhibits the full set of parameters defining ARDS.
- Standardisation of oxygen exposure in the development of mouse models for bronchopulmonary dysplasia
Summary: A newborn mouse model of bronchopulmonary dysplasia in which oxygen injury is systematically standardised recapitulates the two pathological hallmarks of disease.