Table of Contents
- 3D bioprinting: improving in vitro models of metastasis with heterogeneous tumor microenvironments
Summary: Here, Albritton and Miller discuss recent 3D bioprinting advances that can be used to produce heterogeneous tumor microenvironments for improved physical modeling of cancer metastasis.
- A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK- and PI3K-induced malignant growth
Editors' choice: A new brain tumour model in zebrafish allows simultaneous analysis of malignant tumours and heterotopias, suggesting that both lesions originate from similar events, with Yap1 as a driving force in tumour development.
- Prenatal ethanol exposure in mice phenocopies Cdon mutation by impeding Shh function in the etiology of optic nerve hypoplasia
Summary: In utero exposure to ethanol causes defects in optic nerve formation by interfering with Shh signaling activity in the growth and differentiation of retinal progenitor cells in the developing mouse eye.
- Stromal hedgehog signaling maintains smooth muscle and hampers micro-invasive prostate cancer
Summary: New insights are provided into the role of hedgehog signaling in maintaining prostate smooth muscle and place hedgehog as a candidate pathway of therapeutic value for treating individuals with prostate cancer.
- S113R mutation in SLC33A1 leads to neurodegeneration and augmented BMP signaling in a mouse model
Summary: Slc33a1wt/mut knock-in mice with a S113R mutation and exhibiting hereditary spastic paraplegia-related phenotypes show that SLC33A1 negatively regulates BMP signaling and axonal regeneration.
- Standardized echocardiographic assessment of cardiac function in normal adult zebrafish and heart disease models
Summary: Standardization of zebrafish echocardiography provides insights into cardiac physiology in normal and diseased states, with application for functional studies in zebrafish models of heart disease.