Subject collection: Stem Cells
- MAPK signaling pathways and HDAC3 activity are disrupted during differentiation of emerin-null myogenic progenitor cells
Editors' choice: HDAC3, p38 MAPK and ERK signaling are altered during differentiation of myogenic progenitors lacking emerin; pharmacological activation or inhibition of these signaling proteins rescues specific stages of myogenic differentiation.
- ptf1a+, ela3l− cells are developmentally maintained progenitors for exocrine regeneration following extreme loss of acinar cells in zebrafish larvae
Summary: New transgenic models for exocrine pancreas regeneration in zebrafish reveal a novel potential exocrine progenitor as the source for a two-phase regeneration process after complete acinar cell loss.
- A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK- and PI3K-induced malignant growth
Editors' choice: A new brain tumour model in zebrafish allows simultaneous analysis of malignant tumours and heterotopias, suggesting that both lesions originate from similar events, with Yap1 as a driving force in tumour development.
- A human pluripotent stem cell model of catecholaminergic polymorphic ventricular tachycardia recapitulates patient-specific drug responses
Editors' choice: Clinically observed drug response differentials to β-blocker and flecainide treatment in catecholaminergic polymorphic ventricular tachycardia can be modeled in vitro using patient-derived iPSC-cardiomyocytes.
- Cellular dynamics of regeneration reveals role of two distinct Pax7 stem cell populations in larval zebrafish muscle repair
Summary: Tracking muscle precursor cells during wound repair with confocal time-lapse microscopy reveals that two myoblast populations fuse and contribute differentially to regeneration, one initiating and the other growing fibres.
- Stem-cell-specific endocytic degradation defects lead to intestinal dysplasia in Drosophila
Drosophila Collection: Intestinal-stem-cell-specific loss of the Drosophila ortholog of the tumor suppressor UVRAG, which is implicated in colorectal cancer, leads to endocytic defects and dysplasia.
- Abnormal mitochondrial transport and morphology as early pathological changes in human models of spinal muscular atrophy
Summary: This study provides the first evidence in human models of spinal muscular atrophy of impaired mitochondrial dynamics, which serve as potential therapeutic targets for this devastating disease.
- Urine-sample-derived human induced pluripotent stem cells as a model to study PCSK9-mediated autosomal dominant hypercholesterolemia
Summary: The authors used urine-sample-derived patient-specific human induced pluripotent stem cells to generate hepatocytes carrying gain- or loss-of-function mutations of PCSK9, and mimicking the pathophysiology in vitro.
- Human umbilical cord matrix-derived stem cells exert trophic effects on β-cell survival in diabetic rats and isolated islets
Summary: The newly identified paracrine role of umbilical cord stem cells highlights their therapeutic utilities to treat not only the autoimmune-mediated type 1 diabetes but also type 2 diabetes.