Subject collection: Reproductive biology
- The transcriptional repressor Blimp-1 acts downstream of BMP signaling to generate primordial germ cells in the cricket Gryllus bimaculatus
Highlighted article: Blimp-1, a master regulator of PGC formation in mice, acts downstream of BMPs to generate PGCs in the cricket, highlighting that germ cell specification mechanisms are conserved between mice and crickets.
- Sperm-borne miRNAs and endo-siRNAs are important for fertilization and preimplantation embryonic development
Summary: The developmental potential of embryos fertilized with sperm from germline-specific Dicer or Drosha conditional knockout mice is impaired, highlighting key roles for paternal miRNAs/endo-siRNAs.
- Chinmo is sufficient to induce male fate in somatic cells of the adult Drosophila ovary
Highlighted article: Manipulating expression of the transcription factor Chinmo in Drosophila gonads shows that sexual identity can be reprogrammed, and must be actively maintained throughout life.
- Influence of ovarian muscle contraction and oocyte growth on egg chamber elongation in Drosophila
Summary: Contraction of the ovarian muscles helps to produce the elongated shape of the Drosophila egg by stimulating yolk uptake by the oocyte.
- α-Spectrin and integrins act together to regulate actomyosin and columnarization, and to maintain a monolayered follicular epithelium
Summary: α-Spectrin and integrins regulate apical constriction-independent cell elongation, identifying a primary role for α-Spectrin in controlling cell shape.
- Nucleolar activity and CENP-C regulate CENP-A and CAL1 availability for centromere assembly in meiosis
Summary: Novel roles are uncovered for centromere assembly factors CENP-C and CAL1 in meiotic chromosome segregation, CENP-A assembly and maintenance of sperm, as well as fertility in Drosophila males.
- Retinoid signaling controls spermatogonial differentiation by regulating expression of replication-dependent core histone genes
Highlighted article: Upregulation of replication-dependent core histone genes by retinoic acid signaling contributes to spermatogonial differentiation in mice.
- aura (mid1ip1l) regulates the cytoskeleton at the zebrafish egg-to-embryo transition
Summary: The zebrafish maternal-effect gene aura encodes Mid1ip1l, which is involved in cytoskeletal rearrangements during the egg-to-embryo transition.
- Of sex and determination: marking 25 years of Randy, the sex-reversed mouse
Summary: This Spotlight revisits a landmark paper in developmental biology, published 25 years ago, that reported the sex reversal of an XX mouse carrying an Sry transgene.
- SUMO regulates somatic cyst stem cell maintenance and directly targets the Hedgehog pathway in adult Drosophila testis
Summary: SUMOylation promotes proliferation of cyst stem cells in the Drosophila testis. The transcription factor Ci is SUMOylated, enhancing Hedgehog pathway activity in these cells.