Subject collection: Neural development
- Spinal motor neurons are regenerated after mechanical lesion and genetic ablation in larval zebrafish
Summary: Regeneration of spinal motor neurons following mechanical lesion or genetic ablation occurs at the expense of oligodendrogenesis and is promoted by the innate immune system.
- Semaphorin 3A is a retrograde cell death signal in developing sympathetic neurons
Summary: A Sema3A-initiated apoptotic signaling complex regulates the apoptosis of sympathetic neurons during their period of naturally occurring cell death.
- Gene expression profiles uncover individual identities of gnathal neuroblasts and serial homologies in the embryonic CNS of Drosophila
Highlighted article: Characterisation of the neural stem cells in the gnathal head region completes the mapping of all individual neuroblasts that generate the Drosophila CNS.
- Dendritic diversification through transcription factor-mediated suppression of alternative morphologies
Highlighted article: Interactions among Cut, Pdm1/2, Scalloped and Vestigial transcription factors control cell type-specific dendrite morphogenesis in Drosophila sensory neurons.
- Stars from the darkest night: unlocking the neurogenic potential of astrocytes in different brain regions
Summary: This Review discusses the extent to which astrocytes in different brain regions can behave as neural stem cells, and the molecular and environmental factors that either promote or repress such activity.
- Antagonism between Gdf6a and retinoic acid pathways controls timing of retinal neurogenesis and growth of the eye in zebrafish
Summary: In the vertebrate eye, dorsally expressed Gdf6a limits RA pathway activity to control the transition from proliferation to differentiation, thereby regulating eye size.
- The ciliary marginal zone of the zebrafish retina: clonal and time-lapse analysis of a continuously growing tissue
Summary: A quantitative study of cell proliferation and fate choice in the zebrafish retina - a continuously growing neural tissue - reveals key features of late retinal neurogenesis.
- Mutations in the murine homologue of TUBB5 cause microcephaly by perturbing cell cycle progression and inducing p53-associated apoptosis
Highlighted article: New mouse models reveal that human disease-causing mutations in the β-tubulin gene Tubb5 lead to defects in mitotic progression and massive cell death in the cortex.
- Tumor protein Tctp regulates axon development in the embryonic visual system
Highlighted article: The cancer-associated protein Tctp controls neural circuitry in Xenopus via its regulation of pro-survival signalling and axonal mitochondrial homeostasis.
- Drosophila astrocytes cover specific territories of the CNS neuropil and are instructed to differentiate by Prospero, a key effector of Notch
Summary: Clonal analyses of the origins and organization of astrocytes in the Drosophila CNS reveal a regulatory program that acts as a binary switch to distinguish astrocytes from other glial cells.