Subject collection: Model Systems in Drug Discovery
- Miconazole protects blood vessels from MMP9-dependent rupture and hemorrhage
Summary: A phenotype-based chemical screen in zebrafish identifies miconazole as a novel hemorrhagic suppressor. Miconazole inhibits vessel rupture and hemorrhages by decreasing pErk and MMP9 in zebrafish and rats.
- Drug screening using model systems: some basics
Summary: The author provides some tips on what to consider before you begin drug screening.
- Modeling human diseases: an education in interactions and interdisciplinary approaches
Summary: Animal models have greatly facilitated the process of drug discovery. Len Zon draws on his own experiences to highlight how a cross-model, interdisciplinary approach can bring basic findings to the clinic.