Subject collection: Mechanotransduction
- p120-catenin controls contractility along the vertical axis of epithelial lateral membranes
Highlighted Article: The distinct activities of p120 towards E-cadherin and Rho are molecularly and functionally coupled, and this in turn enables the maintenance of cell shape in the larger context of an epithelial monolayer.
- The mechanical regulation of integrin–cadherin crosstalk organizes cells, signaling and forces
Summary: Multiple layers of crosstalk between integrins, cadherins and forces drive spatial organization of signaling and forces within cells.
- The inner workings of stress fibers − from contractile machinery to focal adhesions and back
Summary: Ventral stress fibers play a key role in cellular mechanosensitivity. We discuss here fundamental questions regarding their structure, force-dependent assembly and force generation capacity.
- E-cadherin-mediated force transduction signals regulate global cell mechanics
Summary: Force transduction at E-cadherin junctions operates in addition to unfurling of cadherin-associated α-catenin. This pathway requires EGFR and triggers the downstream activation of integrin-dependent cell contractility.