Subject collection: ESCRT Machinery
- The ESCRT-II proteins are involved in shaping the sarcoplasmic reticulum in C. elegans
Summary: We report that endosomal sorting complex required for transport ESCRT-II proteins are required for the maintenance of the sarcoplasmic reticulum integrity in C. elegans body wall muscle cells.
- ESCRT-0 complex modulates Rbf-mutant cell survival by regulating Rhomboid endosomal trafficking and EGFR signaling
Summary: Inactivation of ESCRT-0 complex promotes Rb-mutant cell death by disrupting Rhomboid endosomal trafficking and inhibiting EGFR signaling.