Subject collection: Cilia and Flagella
- WDR8 is a centriolar satellite and centriole-associated protein that promotes ciliary vesicle docking during ciliogenesis
Summary: WDR8 is a centriolar and pericentriolar satellite protein. WDR8 is targeted to the centrioles by the proximal end protein Cep135. Cep135 and WDR8 are required for ciliary-vesicle docking during ciliogenesis.
- Early eukaryotic origins for cilia-associated bioactive peptide-amidating activity
Highlighted Article: Bioactive peptide amidation is catalyzed by peptidylglycine α-amidating monooxygenase (PAM). Functional PAM is present in Chlamydomonas and cilia, organelles that play key roles in signaling.
- Together, the IFT81 and IFT74 N-termini form the main module for intraflagellar transport of tubulin
Summary: Tubulin transport is specifically impaired by mutations to the proposed tubulin-binding domains of the intraflagellar transport proteins IFT81 and IFT74.
- Two classes of short intraflagellar transport train with different 3D structures are present in Chlamydomonas flagella
Highlighted article: In-depth analyses of IFT train ultrastructure in regenerating Chlamydomonas flagella shows the occurrence of three train types with different 3D structure, implicating differences in function.
- Ttll9−/− mice sperm flagella show shortening of doublet 7, reduction of doublet 5 polyglutamylation and a stall in beating
Highlighted Article: A tubulin polyglutamylase, TTLL9, is involved in the establishment of normal interdoublet heterogeneity of sperm axoneme, and is required for structural integrity and fluid motility of murine sperm flagella.