Subject collection: Cardiovascular development and regeneration
- Cardiac contraction activates endocardial Notch signaling to modulate chamber maturation in zebrafish
Highlighted article: Cardiac contraction, which is sensed by primary cilia, activates Notch signaling in the endocardium to control ventricular trabeculation and maturation during heart development in zebrafish.
- Myocardium and BMP signaling are required for endocardial differentiation
Highlighted article: Interactions between the myocardium and endocardium are important for heart development, with myocardium-derived BMP signals playing a key role in specifying endocardial fate.
- KMT2D regulates specific programs in heart development via histone H3 lysine 4 di-methylation
Highlighted article: Cardiac-specific depletion of the H3K4 methyltransferase KMT2D causes dysregulation of genes associated with cell cycle regulation, ion homeostasis and hypoxia signaling.
- GATA4 regulates Fgf16 to promote heart repair after injury
Highlighted article: GATA4 and FGF16 are important mediators of cardiomyocyte proliferation and hypertrophy during neonatal heart repair following cryoinjury and apex resection.
- Developmental origin and lineage plasticity of endogenous cardiac stem cells
Summary: This Review summarises the different stem cell populations that have been described in the adult mammalian heart, as well their developmental origin and lineage potential both in vivo and in vitro.
- Building and re-building the heart by cardiomyocyte proliferation
Summary: This Review article discusses the cellular and molecular mechanisms that control cardiomyocyte proliferation, during both heart development and regeneration across various species.
- The force within: endocardial development, mechanotransduction and signalling during cardiac morphogenesis
Summary: This Review article presents a comprehensive view of the endocardium: how it develops and then functions as an important angiocrine signalling centre, sensor and transducer of biophysical forces.
- The formation and function of the cardiac conduction system
Summary: This Review discusses the complex gene regulatory networks that act in stage-, tissue- and dose-dependent manners to control the development of the cardiac conduction system.
- View from the heart: cardiac fibroblasts in development, scarring and regeneration
Summary: This Review article looks at the role of cardiac fibroblasts in scarring and regeneration, as well as how these cells are specified during development and the unique characteristics that define them.
- Heartbreak hotel: a convergence in cardiac regeneration
Summary: This Meeting Review summarises the key advances presented at the recent Company of Biologists workshop on Transdifferentiation and Tissue Plasticity in Cardiovascular Rejuvenation.