Disease Models & Mechanisms (DMM) is an online Open Access journal focusing on the use of model systems to better understand, diagnose and treat human disease.
The primary aim of DMM is to promote human health by inspiring collaboration between basic and clinical researchers in translational science, and the journal is committed to presenting rigorously peer-reviewed research that has significant translational impact. The interdisciplinary nature of DMM means that a diverse range of diseases, approaches and models fall within its broad scope. DMM is guided by an international team of expert research-active Editors, led by Monica Justice and Ross Cagan, and the journal is supported by an outstanding Editorial Advisory Board.
Emery–Dreifuss muscular dystrophy (EDMD) is a rare disorder that causes skeletal and cardiac muscle defects. Here, James Holaska and colleagues report that HDAC3, p38 MAPK and ERK signaling are altered during differentiation of myogenic progenitors lacking emerin. Pharmacological targeting of these pathways could promote muscle regeneration, providing a new therapeutic strategy for EDMD.
Also in this issue, Marco Milan and co-authors use a Drosophila model of myeloproliferative neoplasms to provide evidence of pro-tumourigenic crosstalk between the p38 MAPK pathway and JAK signalling.
David Tuveson, Director of the Cancer Center at CSHL, has dedicated many years to understanding pancreatic cancer and developing new models and therapies. In this interview, he describes some of the key moments and breakthroughs in his remarkable career and outlines his vision for the future of cancer research.
News from DMM
Why are we introducing format-free submission?
We realise that submitting your paper to any journal can be a lengthy process. As an author, you are asked to comply with detailed journal-specific guidelines when you don't yet know whether your paper will be accepted or even peer-reviewed. We want to reduce that pain to submit.
What does this mean for you?
You can submit or transfer your paper to DMM in any format. From now on, we will only ask you to do what is absolutely necessary at submission. In practice, this means that other requirements will move to the revision stages - but we hope you won't mind at this point, given that we accept over 95% of revised manuscripts.
As part of this change, and recognising the importance of comprehensive Materials and Methods sections to aid transparency and reproducibility, we are also removing the Materials and Methods section from our length limit to an article. Click here to read more.