Disease Models & Mechanisms (DMM) is an online Open Access journal focusing on the use of model systems to better understand, diagnose and treat human disease.
The primary aim of DMM is to promote human health by inspiring collaboration between basic and clinical researchers in translational science, and the journal is committed to presenting rigorously peer-reviewed research that has significant translational impact. The interdisciplinary nature of DMM means that a diverse range of diseases, approaches and models fall within its broad scope. DMM is guided by an international team of expert research-active Editors, led by Monica Justice and Ross Cagan, and the journal is supported by an outstanding Editorial Advisory Board.
Saima Siddiqi and co-authors describe a novel deafness-dystonia syndrome that is causally related to a loss-of-function mutation in FITM2, the phenotypic effects of which are recapitulated in a Drosophila model.
Also in this issue, Rory Morty and colleagues describe a newborn mouse model of bronchopulmonary dysplasia. The model they present, in which injurious stimuli have been systematically evaluated, provides a most promising approach for the development of new strategies to drive postnatal lung maturation in affected infants.
More from DMM
Read a tribute to Susan Lindquist from DMM's founding Editor-in-Chief, Vivian Siegel.
There is a pressing need to develop new experimental models of Helicobacter-pylori-associated gastric pathology to support novel drug development in this field. In their Review, Mark Pritchard and colleagues discuss the current status of in vivo and ex vivo models of gastric H. pylori colonization, and of Helicobacter-induced gastric pathology.